UniProt O15382
Branched-chain-amino-acid aminotransferase, mitochondrial (O15382)
Branched-chain-amino-acid aminotransferase, mitochondrial (UniProt O15382), EC 2.6.1.42: 49 experimental structures and 1 predicted model on GenesisL1, 11 ligands bound, 7 pockets. Binding sites, druggability and experiment…
- UniProt
- O15382
- Protein
- Branched-chain-amino-acid aminotransferase, mitochondrial
- EC
- 2.6.1.42
- Experimental structures
- 49
- Predicted models
- 1
- Ligands
- 11
- Pockets
- 7 · 1 record with a druggable one
Structures
50 records of O15382 in the MolNFT archive: 49 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1EKF | Crystallographic structure of human branched chain amino acid aminotransferase (mitochondrial)… | x-ray diffraction | A, B | — | — |
| 1EKF | Crystallographic structure of human branched chain amino acid aminotransferase (mitochondrial)… | x-ray diffraction | A, B | — | — |
| 1EKP | Crystal structure of human branched chain amino acid aminotransferase (mitochondrial) complexed… | x-ray diffraction | A, B | — | — |
| 1EKP | Crystal structure of human branched chain amino acid aminotransferase (mitochondrial) complexed… | x-ray diffraction | A, B | — | — |
| 1EKV | Human branched chain amino acid aminotransferase (mitochondrial): three dimensional structure of… | x-ray diffraction | A, B | — | — |
| 1EKV | Human branched chain amino acid aminotransferase (mitochondrial): three dimensional structure of… | x-ray diffraction | A, B | — | — |
| 1KT8 | Human branched chain amino acid aminotransferase (mitochondrial): three dimensional structure of… | x-ray diffraction | A, B | — | — |
| 1KT8 | Human branched chain amino acid aminotransferase (mitochondrial): three dimensional structure of… | x-ray diffraction | A, B | — | — |
| 1KTA | Human branched chain amino acid aminotransferase : three dimensional structure of the enzyme in its… | x-ray diffraction | A, B | — | — |
| 1KTA | Human branched chain amino acid aminotransferase : three dimensional structure of the enzyme in its… | x-ray diffraction | A, B | — | — |
| 2A1H | X-ray crystal structure of human mitochondrial branched chain aminotransferase (BCATm) complexed… | x-ray diffraction | A, B | — | — |
| 2A1H | X-ray crystal structure of human mitochondrial branched chain aminotransferase (bcatm) complexed… | x-ray diffraction | A, B | — | — |
| 2HDK | Crystal Structure of Cys315Ala-Cys318Ala Mutant of Human Mitochondrial Branched Chain… | x-ray diffraction | A, B | — | — |
| 2HDK | Crystal structure of CYS315ALA-CYS318ALA mutant of human mitochondrial branched chain… | x-ray diffraction | A, B | — | — |
| 2HG8 | Crystal Structure of Cys315Ala mutant of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 2HG8 | Crystal structure of CYS315ALA mutant of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 2HGW | Crystal structure of Cys318Ala mutant of human mitochondrial branched chain aminotransferase | x-ray diffraction | A, B | — | — |
| 2HGW | Crystal structure of CYS318ALA mutant of human mitochondrial branched chain aminotransferase | x-ray diffraction | A, B | — | — |
| 2HGX | Crystal structure of Cys315Ala mutant of human mitochondrial branched chain aminotransferase | x-ray diffraction | A, B | — | — |
| 2HGX | Crystal structure of CYS315ALA mutant of human mitochondrial branched chain aminotransferase | x-ray diffraction | A, B | — | — |
| 2HHF | X-ray crystal structure of oxidized human mitochondrial branched chain aminotransferase (hBCATm) | x-ray diffraction | A, B | — | — |
| 2HHF | X-ray crystal structure of oxidized human mitochondrial branched chain aminotransferase (hbcatm) | x-ray diffraction | A, B | — | — |
| 5BWR | X-ray crystal structure at 2.20A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5BWR | X-ray crystal structure at 2.20A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5BWT | X-ray crystal structure at 2.20A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5BWU | X-ray crystal structure at 2.17A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5BWV | X-ray crystal structure at 1.86A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5BWW | X-ray crystal structure at 1.82A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5BWX | X-ray crystal structure at 1.70A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5CR5 | X-ray crystal structure at 1.61A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5HNE | X-ray crystal structure of human mitochondrial branched chain aminotransferase (bcatm) complexed… | x-ray diffraction | A, B | PLP, EL2, CL | — |
| 5HNE | X-ray crystal structure of human mitochondrial branched chain aminotransferase (bcatm) complexed… | x-ray diffraction | A, B | — | — |
| 5I5S | X-ray crystal structure at 2.06A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5I5T | X-ray crystal structure at 2.31A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | PLP, 67X, CL | — |
| 5I5T | X-ray crystal structure at 2.31A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5I5U | X-ray crystal structure at 2.40A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | PLP, 67Y, CL | — |
| 5I5U | X-ray crystal structure at 2.40A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5I5V | X-ray crystal structure at 1.94A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | PLP, 68A, CL | — |
| 5I5V | X-ray crystal structure at 1.94A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5I5W | X-ray crystal structure at 2.40A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | 68B, PLP, CL | — |
| 5I5W | X-ray crystal structure at 2.40A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5I5X | X-ray crystal structure at 1.65A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | PMP, 68C, CL | — |
| 5I5X | X-ray crystal structure at 1.65A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5I5Y | X-ray crystal structure at 1.81A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | PLP, 68D, CL | — |
| 5I5Y | X-ray crystal structure at 1.81A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5I60 | X-ray crystal structure at 2.12A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | PLP, 67W, CL | 7 (best 0.73) |
| 5I60 | X-ray crystal structure at 2.12A resolution of human mitochondrial branched chain aminotransferase… | x-ray diffraction | A, B | — | — |
| 5MPR | Single amino acid variant of human mitochondrial branched chain amino acid aminotransferase 2 | x-ray diffraction | A | PLP | — |
| 6PRX | Oxidized human branched chain aminotransferase mutant C318A | x-ray diffraction | A, B | PLP | — |
| O15382 | AlphaFold monomer V2.0 prediction for branched-chain-amino-acid aminotransferase, mitochondrial… | predicted | A | — | — |
Ligands
- PLP · Pyridoxal-5'-phosphate · in 9 records
- CL · Chloride ion · in 8 records
- 67W · (2-{[4-(1H-pyrazol-3-yl)phenyl]carbamoyl}phenyl)acetic acid · in 1 record
- 67X · (3R)-3-methyl-1,2,3,4-tetrahydroquinoline-8-sulfonamide · in 1 record
- 67Y · 2-hydroxy-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]acetamide · in 1 record
- 68A · 3,5-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid · in 1 record
- 68B · N-(pyrimidin-5-yl)benzamide · in 1 record
- 68C · 5-methyl-4-oxo-N-(1,3,4-thiadiazol-2-yl)-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide · in 1 record
- 68D · {2-[(5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carbonyl)amino]phenyl}acetic acid · in 1 record
- EL2 · 1-[(1R,3S)-3-{[(5-bromothiophen-2-yl)carbonyl]amino}cyclohexyl]-N-methyl-2-(pyridin-2-yl)-1H-benzimidazole-5-carboxamide · in 1 record
- PMP · 4'-deoxy-4'-aminopyridoxal-5'-phosphate · in 1 record
Experiment against prediction
- 5I5X chain A against the predicted model O15382: TM-score 1.00, RMSD 0.34 Å
- 5I5X chain A against the predicted model O15382: TM-score 1.00, RMSD 0.34 Å
- 5BWR chain A against the predicted model O15382: TM-score 1.00, RMSD 0.35 Å
- 5BWR chain A against the predicted model O15382: TM-score 1.00, RMSD 0.35 Å
- 5I5W chain A against the predicted model O15382: TM-score 1.00, RMSD 0.35 Å
- 5I5W chain A against the predicted model O15382: TM-score 1.00, RMSD 0.35 Å
- 5BWW chain A against the predicted model O15382: TM-score 1.00, RMSD 0.34 Å
- 5MPR chain A against the predicted model O15382: TM-score 1.00, RMSD 0.36 Å
- 5BWU chain A against the predicted model O15382: TM-score 1.00, RMSD 0.37 Å
- 6PRX chain A against the predicted model O15382: TM-score 1.00, RMSD 0.41 Å
Elsewhere
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