Glucocorticoid receptor in complex with AZD5423

Structure

x-ray diffraction · 2 distinct chains · 67% helix, 4% strand (DSSP).

Ligands and binding sites

• 8W8 · 2,2,2-tris(fluoranyl)-~{N}-[(1~{R},2~{S})-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl) propan-2-yl]ethanamide · ligand · chains A
• EDO · 1,2-ethanediol · additive · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 652 Ų buried · 16 hydrogen bonds · protein-protein

Compared structures

• 5NFT · Glucocorticoid Receptor in complex with AZD5423 · the same entry in another collection · chain A against A, TM-score 1.00
• P04150 · AlphaFold monomer V2.0 prediction for glucocorticoid receptor (P04150) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P04150
• Every structure of UniProt Q15596
• Elsewhere: RCSB PDB 5NFT · PDBe 5NFT · UniProt P04150 · UniProt Q15596