UniProt Q15596
Nuclear receptor coactivator 2 (Q15596)
Nuclear receptor coactivator 2 (UniProt Q15596): 404 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 8 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q15596
- Protein
- Nuclear receptor coactivator 2
- Experimental structures
- 404
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 8 · 4 records with a druggable one
Structures
405 records of Q15596 in the MolNFT archive: 404 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GWQ | Human oestrogen receptor alpha ligand-binding domain in complex with raloxifene core and TIF2… | x-ray diffraction | C, D | — | — |
| 1GWQ | Human oestrogen receptor alpha ligand-binding domain in complex with raloxifene core and TIF2… | x-ray diffraction | C, D | — | — |
| 1GWR | Human oestrogen receptor alpha ligand-binding domain in complex with 17BETA-oestradiol and TIF2… | x-ray diffraction | C, D | — | — |
| 1GWR | Human oestrogen receptor alpha ligand-binding domain in complex with 17BETA-oestradiol and TIF2… | x-ray diffraction | C, D | — | — |
| 1M2Z | Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain… | x-ray diffraction | B, E | — | — |
| 1M2Z | Crystal structure of a dimer complex of the human glucocorticoid receptor ligand-binding domain… | x-ray diffraction | B, E | — | — |
| 1MV9 | Crystal Structure of the human RXR alpha ligand binding domain bound to the eicosanoid DHA (Docosa… | x-ray diffraction | B | — | — |
| 1MV9 | Crystal structure of the human rxr alpha ligand binding domain bound to the eicosanoid dha (docosa… | x-ray diffraction | B | — | — |
| 1MVC | Crystal structure of the human RXR alpha ligand binding domain bound to the synthetic agonist… | x-ray diffraction | B | — | — |
| 1MVC | Crystal structure of the human rxr alpha ligand binding domain bound to the synthetic agonist… | x-ray diffraction | B | — | — |
| 1MZN | CRYSTAL STRUCTURE at 1.9 ANGSTROEMS RESOLUTION OF THE HOMODIMER OF HUMAN RXR ALPHA LIGAND BINDING… | x-ray diffraction | B, D, F, H | — | — |
| 1MZN | Crystal structure at 1.9 angstroems resolution of the homodimer of human rxr alpha ligand binding… | x-ray diffraction | B, D, F, H | — | — |
| 1P93 | Crystal structure of the agonist form of glucocorticoid receptor | x-ray diffraction | E, F, G, H | — | — |
| 1P93 | Crystal structure of the agonist form of glucocorticoid receptor | x-ray diffraction | E, F, G, H | — | — |
| 1T63 | Crystal Structure of the Androgen Receptor Ligand Binding Domain with DHT and a peptide derived… | x-ray diffraction | B | — | — |
| 1T63 | Crystal structure of the androgen receptor ligand binding domain with dht and a peptide derived… | x-ray diffraction | B | — | — |
| 1T65 | Crystal structure of the androgen receptor ligand binding domain with DHT and a peptide derived… | x-ray diffraction | B | — | — |
| 1T65 | Crystal structure of the androgen receptor ligand binding domain with dht and a peptide derived… | x-ray diffraction | B | — | — |
| 1UHL | Crystal structure of the LXRalfa-RXRbeta LBD heterodimer | x-ray diffraction | C, D | — | — |
| 1UHL | Crystal structure of the lxralfa-rxrbeta lbd heterodimer | x-ray diffraction | C, D | — | — |
| 1YOK | crystal structure of human LRH-1 bound with TIF-2 peptide and phosphatidylglycerol | x-ray diffraction | B, C | — | — |
| 1YOK | Crystal structure of human lrh-1 bound with tif-2 peptide and phosphatidylglycerol | x-ray diffraction | B, C | — | — |
| 1ZDT | The Crystal Structure of Human Steroidogenic Factor-1 | x-ray diffraction | P, Q | — | — |
| 1ZDT | The crystal structure of human steroidogenic factor-1 | x-ray diffraction | P, Q | — | — |
| 1ZDU | The Crystal Structure of Human Liver Receptor Homologue-1 | x-ray diffraction | P, Q | — | — |
| 1ZDU | The crystal structure of human liver receptor homologue-1 | x-ray diffraction | P, Q | — | — |
| 1ZKY | Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-3M and A Glucocorticoid… | x-ray diffraction | C, D | — | — |
| 1ZKY | Human estrogen receptor alpha ligand-binding domain in complex with obcp-3M and a glucocorticoid… | x-ray diffraction | C, D | — | — |
| 2AO6 | Crystal structure of the human androgen receptor ligand binding domain bound with TIF2(iii) 740-753… | x-ray diffraction | B | — | — |
| 2AO6 | Crystal structure of the human androgen receptor ligand binding domain bound with TIF2(III) 740-753… | x-ray diffraction | B | — | — |
| 2B1V | Human estrogen receptor alpha ligand-binding domain in complex with OBCP-1M and a glucocorticoid… | x-ray diffraction | C, D | — | — |
| 2B1V | Human estrogen receptor alpha ligand-binding domain in complex with obcp-1M and a glucocorticoid… | x-ray diffraction | C, D | — | — |
| 2B1Z | Human estrogen receptor alpha ligand-binding domain in complex with… | x-ray diffraction | C, D | — | — |
| 2B1Z | Human estrogen receptor alpha ligand-binding domain in complex with… | x-ray diffraction | C, D | — | — |
| 2B23 | Human estrogen receptor alpha ligand-binding domain and a glucocorticoid receptor-interacting… | x-ray diffraction | C, D | — | — |
| 2B23 | Human estrogen receptor alpha ligand-binding domain and a glucocorticoid receptor-interacting… | x-ray diffraction | C, D | — | — |
| 2FAI | Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-2M and A Glucocorticoid… | x-ray diffraction | C, D | — | — |
| 2FAI | Human estrogen receptor alpha ligand-binding domain in complex with obcp-2M and a glucocorticoid… | x-ray diffraction | C, D | — | — |
| 2G44 | Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-1M-G and A Glucocorticoid… | x-ray diffraction | C, D | — | — |
| 2G44 | Human estrogen receptor alpha ligand-binding domain in complex with obcp-1M-G and a glucocorticoid… | x-ray diffraction | C, D | — | — |
| 2G5O | Human estrogen receptor alpha ligand-binding domain in complex with 2-(but-1-enyl)-17beta-estradiol… | x-ray diffraction | C, D | — | — |
| 2G5O | Human estrogen receptor alpha ligand-binding domain in complex with 2… | x-ray diffraction | C, D | — | — |
| 2P15 | Crystal structure of the ER alpha ligand binding domain with the agonist… | x-ray diffraction | C, D | — | — |
| 2P15 | Crystal structure of the er alpha ligand binding domain with the agonist… | x-ray diffraction | C, D | — | — |
| 2P1T | Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with… | x-ray diffraction | B | — | — |
| 2P1T | Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with… | x-ray diffraction | B | — | — |
| 2P1U | Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with… | x-ray diffraction | B | — | — |
| 2P1U | Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with… | x-ray diffraction | B | — | — |
| 2P1V | Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with… | x-ray diffraction | B | — | — |
| 2P1V | Crystal structure of the ligand binding domain of the retinoid X receptor alpha in complex with… | x-ray diffraction | B | — | — |
| 2Q7J | The Wild Type Androgen Receptor Ligand Binding Domain Bound with Testosterone and a TIF2 box 3… | x-ray diffraction | B | — | — |
| 2Q7J | The wild type androgen receptor ligand binding domain bound with testosterone and a TIF2 box 3… | x-ray diffraction | B | — | — |
| 2Q7L | The Androgen Receptor Prostate Cancer Mutant H874Y Ligand Binding Domain Bound with Testosterone… | x-ray diffraction | B | — | — |
| 2Q7L | The androgen receptor prostate cancer mutant H874Y ligand binding domain bound with testosterone… | x-ray diffraction | B | — | — |
| 2ZXZ | Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist… | x-ray diffraction | B | — | — |
| 2ZXZ | Crystal structure of the human rxr alpha ligand binding domain bound to a synthetic agonist… | x-ray diffraction | B | — | — |
| 2ZY0 | Crystal structure of the human RXR alpha ligand binding domain bound to a synthetic agonist… | x-ray diffraction | B, D | — | — |
| 2ZY0 | Crystal structure of the human rxr alpha ligand binding domain bound to a synthetic agonist… | x-ray diffraction | B, D | — | — |
| 3A9E | Crystal structure of a mixed agonist-bound RAR-alpha and antagonist-bound RXR-alpha heterodimer… | x-ray diffraction | I | — | — |
| 3A9E | Crystal structure of a mixed agonist-bound rar-alpha and antagonist- bound rxr-alpha heterodimer… | x-ray diffraction | I | — | — |
345 records more on the page itself.
Ligands
- ACE · Acetyl group · in 1 record
Experiment against prediction
- 8EV2 chain D against the predicted model Q15596: TM-score 0.96, RMSD 0.11 Å
- 5I4V chain E against the predicted model P55055: TM-score 0.95, RMSD 0.61 Å
- 4IV4 chain D against the predicted model Q15596: TM-score 0.92, RMSD 0.15 Å
- 5I4V chain A against the predicted model P55055: TM-score 0.92, RMSD 1.20 Å
- 1GWQ chain C against the predicted model Q15596: TM-score 0.92, RMSD 0.16 Å
- 2B1V chain C against the predicted model Q15596: TM-score 0.91, RMSD 0.16 Å
- 4IV2 chain D against the predicted model Q15596: TM-score 0.90, RMSD 0.17 Å
- 3L03 chain D against the predicted model Q15596: TM-score 0.90, RMSD 0.17 Å
- 5KCE chain D against the predicted model Q15596: TM-score 0.88, RMSD 0.20 Å
- 4IVW chain D against the predicted model Q15596: TM-score 0.87, RMSD 0.22 Å
Elsewhere
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