Research workbench
Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide
Analyse Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5NAS
- Type
- protein
- Length
- 476 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein ZETA/DELTA; Phosphatidylinositol 4-kinase beta
- EC
- 2.7.1.67
- UniProt
- P63104, Q9UBF8
- Pockets
- 3 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | 14-3-3 protein ZETA/DELTA | protein | 230 | 82% helix, 0% strand | P63104 |
| C, D | Phosphatidylinositol 4-kinase beta (EC 2.7.1.67) | protein | 8 | 0% helix, 0% strand | Q9UBF8 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 318 | 0.55 | 0.75 | 27 | empty |
| 2 | 167 | 0.47 | 0.77 | 22 | empty |
| 3 | 142 | 0.43 | 0.75 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1024 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 587 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 584 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (phosphorylation).
Compared structures
- 5NAS · Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P63104 · AlphaFold monomer V2.0 prediction for 14-3-3 protein ZETA/DELTA (P63104) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9UBF8 · AlphaFold monomer V2.0 prediction for phosphatidylinositol 4-kinase beta (Q9UBF8) · a predicted model of the same protein · chain C against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63104
- Every structure of UniProt Q9UBF8
- Elsewhere: RCSB PDB 5NAS · PDBe 5NAS · UniProt P63104 · UniProt Q9UBF8
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