UniProt Q9UBF8
Phosphatidylinositol 4-kinase beta (Q9UBF8)
Phosphatidylinositol 4-kinase beta (UniProt Q9UBF8), EC 2.7.1.67: 28 experimental structures and 1 predicted model on GenesisL1, 13 ligands bound, 65 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9UBF8
- Protein
- Phosphatidylinositol 4-kinase beta
- EC
- 2.7.1.67
- Experimental structures
- 28
- Predicted models
- 1
- Ligands
- 13
- Pockets
- 65 · 8 records with a druggable one
Structures
29 records of Q9UBF8 in the MolNFT archive: 28 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4D0L | Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with Rab11a- GTP gammaS | x-ray diffraction | A, C, E | — | — |
| 4D0L | Phosphatidylinositol 4-kinase III beta-PIK93 in a complex with RAB11A- GTP gammas | x-ray diffraction | A, C, E | — | — |
| 4D0M | Phosphatidylinositol 4-kinase III beta in a complex with Rab11a-GTP- gamma-S and the Rab-binding… | x-ray diffraction | A, C, G, I, M, O, Q, S, W, Y, c, g | — | — |
| 4D0M | Phosphatidylinositol 4-kinase III beta in a complex with RAB11A-GTP- gamma-S and the rab-binding… | x-ray diffraction | A, C, G, I, M, O, Q, S, W, Y, c, g | — | — |
| 4WAE | Phosphatidylinositol 4-kinase III beta crystallized with ATP | x-ray diffraction | A | — | — |
| 4WAE | Phosphatidylinositol 4-kinase III beta crystallized with ATP | x-ray diffraction | A | — | — |
| 4WAG | Phosphatidylinositol 4-kinase III beta crystallized with MI103 inhibitor | x-ray diffraction | A | — | — |
| 4WAG | Phosphatidylinositol 4-kinase III beta crystallized with MI103 inhibitor | x-ray diffraction | A | — | — |
| 5C46 | Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta in complex… | x-ray diffraction | E | SO4, GSP | 8 (best 0.72) |
| 5C46 | Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta in complex… | x-ray diffraction | E | — | — |
| 5C4G | Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with the… | x-ray diffraction | E | GDP, SO4, BQR | 5 (best 0.68) |
| 5C4G | Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with the… | x-ray diffraction | E | — | — |
| 5EUQ | Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a… | x-ray diffraction | E | GDP, SO4, 5S8 | — |
| 5EUQ | Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta with a… | x-ray diffraction | E | — | — |
| 5FBL | PI4KB in complex with Rab11 and the MI356 Inhibitor | x-ray diffraction | A | 5W9, GSP | 6 (best 0.73) |
| 5FBL | PI4KB in complex with RAB11 and the MI356 inhibitor | x-ray diffraction | A | — | — |
| 5FBQ | PI4KB in complex with Rab11 and the MI358 Inhibitor | x-ray diffraction | A | 5W6 | 11 (best 0.74) |
| 5FBQ | PI4KB in complex with RAB11 and the MI358 inhibitor | x-ray diffraction | A | — | — |
| 5FBR | PI4KB in complex with Rab11 and the MI359 Inhibitor | x-ray diffraction | A | 5W7 | 11 (best 0.73) |
| 5FBR | PI4KB in complex with RAB11 and the MI359 inhibitor | x-ray diffraction | A | — | — |
| 5FBV | PI4KB in complex with Rab11 and the MI364 Inhibitor | x-ray diffraction | A | 5W3, GSP | 8 (best 0.74) |
| 5FBV | PI4KB in complex with RAB11 and the MI364 inhibitor | x-ray diffraction | A | — | — |
| 5FBW | PI4KB in complex with Rab11 and the MI369 Inhibitor | x-ray diffraction | A | 5W8, GSP | — |
| 5FBW | PI4KB in complex with RAB11 and the MI369 inhibitor | x-ray diffraction | A | — | — |
| 5NAS | Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide | x-ray diffraction | C, D | — | 2 (best 0.47) |
| 5NAS | Crystal structure of human 14-3-3 zeta in complex with PI4KIIIB peptide | x-ray diffraction | C, D | — | — |
| 6GL3 | Crystal structure of human phosphatidylinositol 4-kinase III beta (PI4KIIIBETA) in complex with… | x-ray diffraction | A, B | EMW | — |
| 8Q6F | Human PI4KIIIB in complex with covalently bound inhibitor (compound 4) | x-ray diffraction | A | KHR, MG | 4 (best 0.71) |
| Q9UBF8 | AlphaFold monomer V2.0 prediction for phosphatidylinositol 4-kinase beta (Q9UBF8) | predicted | A | — | 10 (best 0.76) |
Ligands
- GSP · 5'-guanosine-diphosphate-monothiophosphate · in 4 records
- SO4 · Sulfate ion · in 3 records
- GDP · Guanosine-5'-diphosphate · in 2 records
- 5S8 · ~{N}-[5-[3-[[(4-hydroxyphenyl)amino]-bis(oxidanyl)-$l^{4}-sulfanyl]-4-methoxy-phenyl]-4-methyl-1,3-thiazol-2-yl]cyclopentanecarboxamide · in 1 record
- 5W3 · ~{N}-[2-[[6-chloranyl-3-[3-(2-hydroxyethylsulfamoyl)-4-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-8-yl]amino]ethy l]ethanamide · in 1 record
- 5W6 · ~{N}-[2-[[6-chloranyl-3-[3-[4-(hydroxymethyl)piperidin-1-yl]sulfonyl-4-methoxy-phenyl]-2-methyl-imidazo[1,2-b]pyridazin-8-yl]amino]ethyl]ethanamide · in 1 record
- 5W7 · ~{N}-[2-[[3-[3-[(4-azanylcyclohexyl)sulfamoyl]-4-methoxy-phenyl]-6-chloranyl-2-methyl-imidazo[1,2-b]pyridazin-8-yl]amino]ethyl]ethanamide · in 1 record
- 5W8 · ~{N}-[2-[[6-chloranyl-3-[4-methoxy-3-[[(2~{R})-1-oxidanylbutan-2-yl]sulfamoyl]phenyl]-2-methyl-imidazo[1,2-b]pyridazin-8-yl]amino]ethyl]ethanamide · in 1 record
- 5W9 · ~{N}-[2-[[6-chloranyl-3-(4-methoxy-3-morpholin-4-ylsulfonyl-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-8-yl]amino]ethyl]ethanamide · in 1 record
- BQR · N~2~-[7-(3,4-dimethoxyphenyl)quinoxalin-2-yl]-N-methylglycinamide · in 1 record
- EMW · (3~{S})-4-(6-azanyl-1-methyl-pyrazolo[3,4-d]pyrimidin-4-yl)-~{N}-(4-methoxy-2-methyl-phenyl)-3-methyl-piperazine-1-carboxamide · in 1 record
- KHR · 3-(3-fluorosulfonyloxy-4-methoxy-phenyl)-2,5-dimethyl-7-(pyridin-4-ylmethylamino)pyrazolo[1,5-a]pyrimidine · in 1 record
- MG · Magnesium ion · in 1 record
Experiment against prediction
- 5FBR chain A against the predicted model Q9UBF8: TM-score 0.99, RMSD 0.89 Å
- 5FBR chain A against the predicted model Q9UBF8: TM-score 0.99, RMSD 0.89 Å
- 5FBL chain A against the predicted model Q9UBF8: TM-score 0.99, RMSD 0.90 Å
- 5FBL chain A against the predicted model Q9UBF8: TM-score 0.99, RMSD 0.90 Å
- 5FBV chain A against the predicted model Q9UBF8: TM-score 0.99, RMSD 0.94 Å
- 5FBV chain A against the predicted model Q9UBF8: TM-score 0.99, RMSD 0.94 Å
- 5FBW chain A against the predicted model Q9UBF8: TM-score 0.99, RMSD 0.94 Å
- 5FBW chain A against the predicted model Q9UBF8: TM-score 0.99, RMSD 0.94 Å
- 5EUQ chain E against the predicted model Q9UBF8: TM-score 0.99, RMSD 1.03 Å
- 5EUQ chain E against the predicted model Q9UBF8: TM-score 0.99, RMSD 1.03 Å
Elsewhere
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