Research workbench
Human PDK1-pkciota kinase chimera in complex with allosteric compound PS267 bound to the pif-pocket
Analyse Human PDK1-pkciota kinase chimera in complex with allosteric compound PS267… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5MRD
- Type
- protein
- Length
- 284 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3-phosphoinositide-dependent protein kinase 1
- EC
- 2.7.11.1
- UniProt
- O15530
- Ligands
- S26, ATP
- Pockets
- 2 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 41% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 3-phosphoinositide-dependent protein kinase 1 (EC 2.7.11.1) | protein | 284 | 41% helix, 18% strand | O15530 |
Ligands and binding sites
- S26 · ethyl (2~{S})-1-(6-chloranyl-1,3-benzothiazol-2-yl)-4-oxidanyl-5-oxidanylidene-2-thiophen-2-yl-2~{H}-pyrrole-3-carboxylate · ligand · chains A
- ATP · Adenosine-5'-triphosphate · ligand · chains A
- DMS · Dimethyl sulfoxide · additive · 2 copies · chains A
- DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 269 | 0.60 | 0.79 | 27 | ATP |
| 2 | 66 | 0.35 | 0.77 | 23 | empty |
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 5MRD · Human PDK1-PKCiota Kinase Chimera in Complex with Allosteric Compound PS267 Bound to the… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15530
- Elsewhere: RCSB PDB 5MRD · PDBe 5MRD · UniProt O15530
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