UniProt O15530
3-phosphoinositide-dependent protein kinase 1 (O15530)
3-phosphoinositide-dependent protein kinase 1 (UniProt O15530), EC 2.7.11.1: 129 experimental structures on GenesisL1, 13 ligands bound, 3 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- O15530
- Protein
- 3-phosphoinositide-dependent protein kinase 1
- EC
- 2.7.11.1
- Experimental structures
- 129
- Predicted models
- 0
- Ligands
- 13
- Pockets
- 3 · 2 records with a druggable one
Structures
129 records of O15530 in the MolNFT archive: 129 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1H1W | High resolution crystal structure of the human PDK1 catalytic domain | x-ray diffraction | A | — | — |
| 1H1W | High resolution crystal structure of the human PDK1 catalytic domain | x-ray diffraction | A | — | — |
| 1OKY | Structure of human PDK1 kinase domain in complex with staurosporine | x-ray diffraction | A | — | — |
| 1OKY | Structure of human PDK1 kinase domain in complex with staurosporine | x-ray diffraction | A | — | — |
| 1OKZ | Structure of human PDK1 kinase domain in complex with UCN-01 | x-ray diffraction | A | — | — |
| 1OKZ | Structure of human PDK1 kinase domain in complex with ucn-01 | x-ray diffraction | A | — | — |
| 1UU3 | Structure of human PDK1 kinase domain in complex with LY333531 | x-ray diffraction | A | — | — |
| 1UU3 | Structure of human PDK1 kinase domain in complex with LY333531 | x-ray diffraction | A | — | — |
| 1UU7 | Structure of human PDK1 kinase domain in complex with BIM-2 | x-ray diffraction | A | — | — |
| 1UU7 | Structure of human PDK1 kinase domain in complex with bim-2 | x-ray diffraction | A | — | — |
| 1UU8 | Structure of human PDK1 kinase domain in complex with BIM-1 | x-ray diffraction | A | — | — |
| 1UU8 | Structure of human PDK1 kinase domain in complex with bim-1 | x-ray diffraction | A | — | — |
| 1UU9 | Structure of human PDK1 kinase domain in complex with BIM-3 | x-ray diffraction | A | — | — |
| 1UU9 | Structure of human PDK1 kinase domain in complex with bim-3 | x-ray diffraction | A | — | — |
| 1UVR | Structure of human PDK1 kinase domain in complex with BIM-8 | x-ray diffraction | A | — | — |
| 1UVR | Structure of human PDK1 kinase domain in complex with bim-8 | x-ray diffraction | A | — | — |
| 1W1D | Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain bound to Inositol… | x-ray diffraction | A | — | — |
| 1W1D | Crystal structure of the PDK1 pleckstrin homology (pH) domain bound to inositol… | x-ray diffraction | A | — | — |
| 1W1G | Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain bound to DiC4-phosphatidylinositol… | x-ray diffraction | A | — | — |
| 1W1G | Crystal structure of the PDK1 pleckstrin homology (pH) domain bound to DIC4-phosphatidylinositol… | x-ray diffraction | A | — | — |
| 1W1H | Crystal Structure of the PDK1 Pleckstrin Homology (PH) domain | x-ray diffraction | A, B, C, D | — | — |
| 1W1H | Crystal structure of the PDK1 pleckstrin homology (pH) domain | x-ray diffraction | A, B, C, D | — | — |
| 1Z5M | Crystal Structure Of N1-[3-[[5-bromo-2-[[3-[(1-pyrrolidinylcarbonyl)amino]phenyl]amino]-4-pyrimidiny… | x-ray diffraction | A | — | — |
| 1Z5M | Crystal structure of N1-[3-[[5-bromo-2-[[3-[(1-pyrrolidinylcarbonyl)… | x-ray diffraction | A | — | — |
| 2BIY | Structure of PDK1-S241A mutant kinase domain | x-ray diffraction | A | — | — |
| 2BIY | Structure of PDK1-S241A mutant kinase domain | x-ray diffraction | A | — | — |
| 2PE0 | CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1)… | x-ray diffraction | A | — | — |
| 2PE0 | Crystal structure of human phosphoinositide-dependent protein kinase 1 (PDK1)… | x-ray diffraction | A | — | — |
| 2PE1 | CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1)… | x-ray diffraction | A | — | — |
| 2PE1 | Crystal structure of human phosphoinositide-dependent protein kinase 1 (PDK1)… | x-ray diffraction | A | — | — |
| 2PE2 | CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1)… | x-ray diffraction | A | — | — |
| 2PE2 | Crystal structure of human phosphoinositide-dependent protein kinase 1 (PDK1)… | x-ray diffraction | A | — | — |
| 2R7B | Crystal Structure of the Phosphoinositide-dependent Kinase-1 (PDK-1)Catalytic Domain bound to a… | x-ray diffraction | A | — | — |
| 2R7B | Crystal structure of the phosphoinositide-dependent kinase- 1 (pdk-1)CATALYTIC domain bound to a… | x-ray diffraction | A | — | — |
| 2VKI | Structure of the PDK1 PH domain K465E mutant | x-ray diffraction | A | — | — |
| 2VKI | Structure of the PDK1 pH domain K465E mutant | x-ray diffraction | A | — | — |
| 2XCH | Crystal structure of PDK1 in complex with a pyrazoloquinazoline inhibitor | x-ray diffraction | A | — | — |
| 2XCH | Crystal structure of PDK1 in complex with a pyrazoloquinazoline inhibitor | x-ray diffraction | A | — | — |
| 2XCK | Crystal structure of PDK1 in complex with a pyrazoloquinazoline inhibitor | x-ray diffraction | A | — | — |
| 2XCK | Crystal structure of PDK1 in complex with a pyrazoloquinazoline inhibitor | x-ray diffraction | A | — | — |
| 3H9O | Phosphoinositide-dependent protein kinase 1 (PDK-1) in complex with compound 9 | x-ray diffraction | A | — | — |
| 3H9O | Phosphoinositide-dependent protein kinase 1 (pdk-1) in complex with compound 9 | x-ray diffraction | A | — | — |
| 3HRC | Crystal structure of a mutant of human PDK1 Kinase domain in complex with ATP | x-ray diffraction | A | — | — |
| 3HRC | Crystal structure of a mutant of human PDK1 kinase domain in complex with ATP | x-ray diffraction | A | — | — |
| 3HRF | Crystal structure of Human PDK1 kinase domain in complex with an allosteric activator bound to the… | x-ray diffraction | A | — | — |
| 3HRF | Crystal structure of human PDK1 kinase domain in complex with an allosteric activator bound to the… | x-ray diffraction | A | — | — |
| 3ION | PDK1 in complex with Compound 8h | x-ray diffraction | A | — | — |
| 3ION | PDK1 in complex with compound 8H | x-ray diffraction | A | — | — |
| 3IOP | PDK-1 in complex with the inhibitor Compound-8i | x-ray diffraction | A | — | — |
| 3IOP | Pdk-1 in complex with the inhibitor compound-8I | x-ray diffraction | A | — | — |
| 3NAX | PDK1 in complex with inhibitor MP7 | x-ray diffraction | A | — | — |
| 3NAX | PDK1 in complex with inhibitor MP7 | x-ray diffraction | A | — | — |
| 3NAY | PDK1 in complex with inhibitor MP6 | x-ray diffraction | A, B | — | — |
| 3NAY | PDK1 in complex with inhibitor MP6 | x-ray diffraction | A, B | — | — |
| 3ORX | PDK1 mutant bound to allosteric disulfide fragment inhibitor 1F8 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3ORX | PDK1 mutant bound to allosteric disulfide fragment inhibitor 1F8 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 3ORZ | PDK1 mutant bound to allosteric disulfide fragment activator 2A2 | x-ray diffraction | A, B, C, D | — | — |
| 3ORZ | PDK1 mutant bound to allosteric disulfide fragment activator 2A2 | x-ray diffraction | A, B, C, D | — | — |
| 3OTU | PDK1 mutant bound to allosteric disulfide fragment activator JS30 | x-ray diffraction | A | — | — |
| 3OTU | PDK1 mutant bound to allosteric disulfide fragment activator JS30 | x-ray diffraction | A | — | — |
69 records more on the page itself.
Ligands
- ATP · Adenosine-5'-triphosphate · in 4 records
- CL · Chloride ion · in 4 records
- SO4 · Sulfate ion · in 4 records
- 537 · 2,6-dihydroanthra/1,9-cd/pyrazol-6-one · in 2 records
- ADE · Adenine · in 2 records
- ADN · Adenosine · in 2 records
- 61Y · 4-ethyl-6-[5-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridin-3-yl]pyrimidin-2-amine · in 1 record
- 62O · 6-methoxy-2-(1H-pyrazol-5-yl)-1H-benzimidazole · in 1 record
- 63E · 4-butyl-6-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine · in 1 record
- 63L · 5-amino-3-(methylsulfanyl)-1H-pyrazole-1,4-dicarboxamide · in 1 record
- 78W · 2-oxidanylidenepropyl ~{N}-(2-chloranyl-6-fluoranyl-phenyl)carbonyl-~{N}'-(4-chlorophenyl) carbamimidothioate · in 1 record
- ACE · Acetyl group · in 1 record
- S26 · Ethyl (2~{S})-1-(6-chloranyl-1,3-benzothiazol-2-yl)-4-oxidanyl-5-oxidanylidene-2-thiophen-2-yl-2~{H}-pyrrole-3-carboxylate · in 1 record
Elsewhere
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