Research workbench
Crystal structure of yeast HSH49P in complex with CUS1P binding domain.
Analyse Crystal structure of yeast HSH49P in complex with CUS1P binding domain. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5LSB
- Type
- protein
- Length
- 712 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein HSH49; Cold sensitive U2 snrna suppressor 1
- UniProt
- Q99181, Q02554
- Pockets
- 3 · best druggability 0.50
Structure
x-ray diffraction · 3 distinct chains · 27% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Protein HSH49 | protein | 176 | 26% helix, 34% strand | Q99181 |
| B, D, H | Cold sensitive U2 snrna suppressor 1 | protein | 62 | 27% helix, 18% strand | Q02554 |
| F | Protein HSH49 | protein | 174 | 29% helix, 33% strand | Q99181 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 175 | 0.50 | 0.77 | 26 | empty |
| 2 | 124 | 0.43 | 0.76 | 16 | empty |
| 3 | 114 | 0.42 | 0.77 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1016 Ų buried · 17 hydrogen bonds · protein-protein
- C–D · 1010 Ų buried · 17 hydrogen bonds · protein-protein
- F–H · 1001 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
- 5LSB · Crystal structure of yeast Hsh49p in complex with Cus1p binding domain. · the same entry in another collection · chain H against H, TM-score 1.00
- Q02554 · AlphaFold monomer V2.0 prediction for cold sensitive U2 snrna suppressor 1 (Q02554) · a predicted model of the same protein · chain H against A, TM-score 0.98
- Q99181 · AlphaFold monomer V2.0 prediction for protein HSH49 (Q99181) · a predicted model of the same protein · chain F against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99181
- Every structure of UniProt Q02554
- Elsewhere: RCSB PDB 5LSB · PDBe 5LSB · UniProt Q99181 · UniProt Q02554
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