Research workbench
Glge isoform 1 from streptomyces coelicolor D394A mutant co- crystallised with maltodextrin
Analyse Glge isoform 1 from streptomyces coelicolor D394A mutant co- crystallised with… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5LGW
- Type
- protein
- Length
- 1,296 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Alpha-1,4-GLUCAN:MALTOSE-1-phosphate maltosyltransferase 1
- EC
- 2.4.99.16
- UniProt
- Q9L1K2
- Ligands
- GLC, BGC
- Pockets
- 13 · best druggability 0.77
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Alpha-1,4-GLUCAN:MALTOSE-1-phosphate maltosyltransferase 1 (EC 2.4.99.16) | protein | 648 | 35% helix, 25% strand | Q9L1K2 |
Ligands and binding sites
- GLC · alpha-D-glucopyranose · sugar · 27 copies · chains B, A
- BGC · beta-D-glucopyranose · sugar · 2 copies · chains A, B
- EDO · 1,2-ethanediol · additive · 4 copies · chains A, B
- CIT · Citric acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 829 | 0.77 | 0.80 | 54 | EDO |
| 2 | 1065 | 0.76 | 0.79 | 116 | empty |
| 3 | 818 | 0.76 | 0.80 | 54 | EDO |
| 4 | 265 | 0.68 | 0.84 | 32 | BGC, GLC, EDO |
| 5 | 276 | 0.68 | 0.83 | 34 | BGC, GLC, EDO |
Interfaces
1 interface between chains.
- A–B · 2285 Ų buried · 33 hydrogen bonds · protein-protein
Compared structures
- 5LGW · GlgE isoform 1 from Streptomyces coelicolor D394A mutant co-crystallised with maltodextrin · the same entry in another collection · chain A against A, TM-score 1.00
- Q9L1K2 · AlphaFold monomer V2.0 prediction for alpha-1,4-GLUCAN:MALTOSE-1-phosphate… · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9L1K2
- Elsewhere: RCSB PDB 5LGW · PDBe 5LGW · UniProt Q9L1K2
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