Hif prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with MN(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl) CARBONYL]GLYCINE (IOX3/FG2216)

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 29% strand (DSSP).

Ligands and binding sites

• UN9 · N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine · ligand · chains A
• BCT · Bicarbonate ion · ligand · chains A
• MN · Manganese (II) ion · metal · chains A
• SO4 · Sulfate ion · ion · 2 copies · chains A
• CL · Chloride ion · ion · chains A
• GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Compared structures

• 5LBC · HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II)… · the same entry in another collection · chain A against A, TM-score 1.00
• Q9GZT9 · AlphaFold monomer V2.0 prediction for egl nine homolog 1 (Q9GZT9) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9GZT9
• Elsewhere: RCSB PDB 5LBC · PDBe 5LBC · UniProt Q9GZT9