MolNFT v2 · #125888 · protein

HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)

5LBC: “HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and…”. X-ray diffraction at 1.816, 5 ligands (UN9, BCT, MN). MolNFT v2 #125888 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5LBC
Type: protein
Length: 222 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.816
Source: Homo sapiens
UniProt: Q9GZT9
Ligands: UN9, BCT, MN, SO4, CL

Structure

x-ray diffraction · resolution 1.816 · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	222	—	Q9GZT9

Ligands and binding sites

UN9 · N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine · ligand · chains A
BCT · Bicarbonate ion · ligand · chains A
MN · Manganese (II) ion · metal · chains A
SO4 · Sulfate ion · ion · 2 copies · chains A
CL · Chloride ion · ion · chains A
GOL · Glycerol · additive · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5LBC · Hif prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with MN(II)… · the same entry in another collection · chain A against A, TM-score 1.00
Q9GZT9 · AlphaFold monomer V2.0 prediction for egl nine homolog 1 (Q9GZT9) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9GZT9
Elsewhere: RCSB PDB 5LBC · PDBe 5LBC · UniProt Q9GZT9

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