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Structure of the human GLUN1/GLUN2A lbd in complex with GNE6901

Analyse Structure of the human GLUN1/GLUN2A lbd in complex with GNE6901 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5KCJ
Type: protein
Length: 561 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q12879, Q05586
Ligands: 6RM

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	280	—	Q12879
B	—	protein	281	—	Q05586

Ligands and binding sites

6RM · 7-[(4-fluoranylphenoxy)methyl]-3-[(1~{R},2~{R})-2-(hydroxymethyl)cyclopropyl]-2-methyl-[1,3]thiazolo[3, 2-a]pyrimidin-5-one · ligand · chains A, B
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5KCJ · Structure of the human GluN1/GluN2A LBD in complex with GNE6901 · the same entry in another collection · chain B against B, TM-score 1.00
Q12879 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2A (Q12879) · a predicted model of the same protein · chain A against A, TM-score 0.97
Q05586 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 1 (Q05586) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q12879
Every structure of UniProt Q05586
Elsewhere: RCSB PDB 5KCJ · PDBe 5KCJ · UniProt Q12879 · UniProt Q05586

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