UniProt Q05586
Glutamate receptor ionotropic, NMDA 1 (Q05586)
Glutamate receptor ionotropic, NMDA 1 (UniProt Q05586): 50 experimental structures on GenesisL1, 18 ligands bound, 164 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q05586
- Protein
- Glutamate receptor ionotropic, NMDA 1
- Experimental structures
- 50
- Predicted models
- 0
- Ligands
- 18
- Pockets
- 164 · 16 records with a druggable one
Structures
50 records of Q05586 in the MolNFT archive: 50 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2HQW | Crystal Structure of Ca2+/Calmodulin bound to NMDA Receptor NR1C1 peptide | x-ray diffraction | B | — | — |
| 2HQW | Crystal structure of CA2+/CALMODULIN bound to NMDA receptor NR1C1 peptide | x-ray diffraction | B | — | — |
| 2NR1 | Transmembrane segment 2 of NMDA receptor NR1, NMR, 10 structures | solution nmr | A | — | — |
| 2NR1 | Transmembrane segment 2 of NMDA receptor NR1, NMR, 10 structures | solution nmr | A | — | — |
| 3BYA | Structure of a Calmodulin Complex | x-ray diffraction | B | — | — |
| 3BYA | Structure of a calmodulin complex | x-ray diffraction | B | — | — |
| 5H8F | Structure of the apo human GluN1/GluN2A LBD | x-ray diffraction | B | — | — |
| 5H8F | Structure of the apo human GLUN1/GLUN2A lbd | x-ray diffraction | B | — | — |
| 5H8H | Structure of the human GLUN1/GLUN2A lbd in complex with GNE3419 | x-ray diffraction | B | — | — |
| 5H8N | Structure of the human GluN1/GluN2A LBD in complex with NAM | x-ray diffraction | B | 5YD, CA | — |
| 5H8N | Structure of the human GLUN1/GLUN2A lbd in complex with nam | x-ray diffraction | B | — | — |
| 5H8Q | Structure of the human GluN1/GluN2A LBD in complex with GNE8324 | x-ray diffraction | B | 5YE | — |
| 5H8Q | Structure of the human GLUN1/GLUN2A lbd in complex with GNE8324 | x-ray diffraction | B | — | — |
| 5I2K | Structure of the human GluN1/GluN2A LBD in complex with… | x-ray diffraction | B | GLY, 67H | 6 (best 0.77) |
| 5I2K | Structure of the human GLUN1/GLUN2A lbd in complex with 7-{[ETHYL(4… | x-ray diffraction | B | — | — |
| 5I2N | Structure of the human GLUN1/GLUN2A lbd in complex with N-ethyl-7-{[2… | x-ray diffraction | B | — | — |
| 5KCJ | Structure of the human GluN1/GluN2A LBD in complex with GNE6901 | x-ray diffraction | B | GLY, 6RM | 4 (best 0.80) |
| 5KCJ | Structure of the human GLUN1/GLUN2A lbd in complex with GNE6901 | x-ray diffraction | B | 6RM | — |
| 5KDT | Structure of the human GluN1/GluN2A LBD in complex with GNE0723 | x-ray diffraction | B | 6RV, GLY | 4 (best 0.78) |
| 5KDT | Structure of the human GLUN1/GLUN2A lbd in complex with GNE0723 | x-ray diffraction | B | 6RV | — |
| 5TP9 | Structure of the human GLUN1/GLUN2A lbd in complex with compound 2 (GNE9178) | x-ray diffraction | B | 7H0, CA | — |
| 5TPA | Structure of the human GLUN1/GLUN2A lbd in complex with compound 9 (GNE3500) | x-ray diffraction | B | 7H2 | — |
| 6IRA | Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 7.8 | electron microscopy | A, C | — | — |
| 6IRA | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLUTAMATE/GLYCINE-bound state at pH 7.8 | electron microscopy | A, C | — | — |
| 6IRF | Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3… | electron microscopy | A, C | — | — |
| 6IRF | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLUTAMATE/GLYCINE-bound state at pH 6.3… | electron microscopy | A, C | — | — |
| 6IRG | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLUTAMATE/GLYCINE-bound state at pH 6.3… | electron microscopy | C, A | — | — |
| 6IRH | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLUTAMATE/GLYCINE-bound state at pH 6.3… | electron microscopy | C, A | — | — |
| 7EOQ | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLYCINE/CPP bound state | electron microscopy | B, D | NAG | — |
| 7EOR | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLYCINE/GLUTAMATE/GNE-6901 bound state | electron microscopy | B, D | 6RM, NAG | — |
| 7EOS | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLYCINE/GLUTAMATE bound state | electron microscopy | B, D | NAG | — |
| 7EOT | Structure of the human GLUN1/GLUN2A NMDA receptor in the cgp- 78608/GLUTAMATE bound state | electron microscopy | B, D | NAG, J86 | — |
| 7EOU | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLYCINE/GLUTAMATE/GNE-6901/9-aa bound state | electron microscopy | B, D | NAG, 6RM | — |
| 7EU7 | Structure of the human GluN1-GluN2A NMDA receptor in complex with S-ketamine, glycine and glutamate | electron microscopy | A, C | NAG | — |
| 7EU7 | Structure of the human GLUN1-GLUN2A NMDA receptor in complex with S- ketamine, glycine and glutamate | electron microscopy | A, C | NAG | — |
| 7EU8 | Structure of the human GLUN1-GLUN2B NMDA receptor in complex with S- KETAMINE,GLYCINE and glutamate | electron microscopy | A, C | NAG, JC9 | — |
| 7YFL | Structure of GluN1a-GluN2D NMDA receptor in complex with agonists glycine and glutamate. | electron microscopy | A, C | NAG, GLY | 17 (best 0.85) |
| 7YFO | Structure of GluN1a E698C-GluN2D NMDA receptor in cystines crosslinked state. | electron microscopy | A, C | — | 15 (best 0.84) |
| 8E93 | D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in splayed conformation | electron microscopy | A, C | NAG, BMA | 15 (best 0.86) |
| 8E94 | PYD-106-bound Human GluN1a-GluN2C NMDA receptor in intact conformation | electron microscopy | A, C | NAG | 13 (best 0.82) |
| 8E98 | D-cycloserine and glutamate bound Human GluN1a-GluN2C NMDA receptor in nanodisc - intact… | electron microscopy | A, C | NAG | 13 (best 0.86) |
| 8JIZ | Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation | electron microscopy | B, D | NAG | 15 (best 0.87) |
| 8USX | Glycine-bound GluN1a-3A NMDA receptor | electron microscopy | A, C | — | 12 (best 0.82) |
| 8VUR | Human GluN1-2A with IgG 003-102 WT conformation | electron microscopy | A, C | — | 17 (best 0.85) |
| 8VUU | Human GluN1-2B with Fab 007-168 | electron microscopy | A, C | — | 16 (best 0.84) |
| 9GIB | NMDA bound to compound 380 | x-ray diffraction | B | A1ILP, SO4 | 4 (best 0.78) |
| 9GIC | NMDA bound to compound 345 | x-ray diffraction | A | A1ILQ, SO4 | 5 (best 0.62) |
| 9GID | NMDA bound to compound 338 | x-ray diffraction | A | A1ILT, SO4 | 5 (best 0.65) |
| 9GIG | NMDA bound to compound 387 | x-ray diffraction | B | A1ILO | 3 (best 0.81) |
| Q05586 | AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 1 (Q05586) | — | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 13 records
- 6RM · 7-[(4-fluoranylphenoxy)methyl]-3-[(1~{R},2~{R})-2-(hydroxymethyl)cyclopropyl]-2-methyl-[1,3]thiazolo[3, 2-a]pyrimidin-5-one · in 4 records
- GLY · Glycine · in 4 records
- SO4 · Sulfate ion · in 3 records
- 6RV · (1~{R},2~{R})-2-[7-[[5-chloranyl-3-(trifluoromethyl) pyrazol-1-yl]methyl]-5-oxidanylidene-2-(trifluoromethyl)-[1,3]thiazolo[3,2-a]pyrimidin-3-yl]cyclopropane-1-carbonitrile · in 2 records
- CA · Calcium ion · in 2 records
- 5YD · 4-[[(4-fluorophenyl)sulfonylamino]methyl]-~{N}-(pyridin-3-ylmethyl)benzamide · in 1 record
- 5YE · 6-[[ethyl-(4-fluorophenyl)amino]methyl]-2,3-dihydro-1~{H}-cyclopenta[3,4][1,3]thiazolo[1,4-~{a}]pyrimidin-8-one · in 1 record
- 67H · 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide · in 1 record
- 7H0 · 7-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-N-ethyl-2-methyl-5-oxo-5H-[1,3]thiazolo[3, 2-a]pyrimidine-3-carboxamide · in 1 record
- 7H2 · (1R,2R)-2-(2-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropane-1-carbonitrile · in 1 record
- A1ILO · (2~{R})-2-azanyl-3-[[3-(5-ethyl-3-methyl-1,2-oxazol-4-yl)-5-fluoranyl-phenyl]carbonylamino]propanoic acid · in 1 record
- A1ILP · (2~{R})-2-azanyl-3-[[3-(5-ethyl-1,2-oxazol-4-yl)-5-fluoranyl-phenyl]carbonylamino]propanoic acid · in 1 record
- A1ILQ · (2~{R})-2-azanyl-3-[[3-(phenylmethyl)-2~{H}-thiophen-5-yl]carbonylamino]propanoic acid · in 1 record
- A1ILT · (2~{R})-2-azanyl-3-[(7-bromanyl-4-fluoranyl-3~{H}-1-benzothiophen-2-yl)carbonylamino]propanoic acid · in 1 record
- BMA · beta-D-mannopyranose · in 1 record
- J86 · [(1S)-1-[[7-bromanyl-2,3-bis(oxidanylidene)-1,4-dihydroquinoxalin-5-yl]methylamino]ethyl]phosphonic acid · in 1 record
- JC9 · (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one · in 1 record
Elsewhere
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