UniProt Q12879
Glutamate receptor ionotropic, NMDA 2A (Q12879)
Glutamate receptor ionotropic, NMDA 2A (UniProt Q12879): 34 experimental structures on GenesisL1, 11 ligands bound, 45 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q12879
- Protein
- Glutamate receptor ionotropic, NMDA 2A
- Experimental structures
- 34
- Predicted models
- 0
- Ligands
- 11
- Pockets
- 45 · 5 records with a druggable one
Structures
34 records of Q12879 in the MolNFT archive: 34 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3NFL | Crystal structure of the PTPN4 PDZ domain complexed with the C-terminus of the GluN2A NMDA receptor… | x-ray diffraction | E, F, G, H | — | — |
| 3NFL | Crystal structure of the PTPN4 PDZ domain complexed with the C- terminus of the GLUN2A NMDA… | x-ray diffraction | E, F, G, H | — | — |
| 5H8F | Structure of the apo human GluN1/GluN2A LBD | x-ray diffraction | A | — | — |
| 5H8F | Structure of the apo human GLUN1/GLUN2A lbd | x-ray diffraction | A | — | — |
| 5H8H | Structure of the human GLUN1/GLUN2A lbd in complex with GNE3419 | x-ray diffraction | A | — | — |
| 5H8N | Structure of the human GluN1/GluN2A LBD in complex with NAM | x-ray diffraction | A | 5YD | — |
| 5H8N | Structure of the human GLUN1/GLUN2A lbd in complex with nam | x-ray diffraction | A | — | — |
| 5H8Q | Structure of the human GluN1/GluN2A LBD in complex with GNE8324 | x-ray diffraction | A | 5YE | — |
| 5H8Q | Structure of the human GLUN1/GLUN2A lbd in complex with GNE8324 | x-ray diffraction | A | — | — |
| 5I2K | Structure of the human GluN1/GluN2A LBD in complex with… | x-ray diffraction | A | GLU, 67H | 5 (best 0.77) |
| 5I2K | Structure of the human GLUN1/GLUN2A lbd in complex with 7-{[ETHYL(4… | x-ray diffraction | A | — | — |
| 5I2N | Structure of the human GLUN1/GLUN2A lbd in complex with N-ethyl-7-{[2… | x-ray diffraction | A | — | — |
| 5KCJ | Structure of the human GluN1/GluN2A LBD in complex with GNE6901 | x-ray diffraction | A | GLU, 6RM | 4 (best 0.80) |
| 5KCJ | Structure of the human GLUN1/GLUN2A lbd in complex with GNE6901 | x-ray diffraction | A | 6RM | — |
| 5KDT | Structure of the human GluN1/GluN2A LBD in complex with GNE0723 | x-ray diffraction | A | GLU, 6RV | 4 (best 0.78) |
| 5KDT | Structure of the human GLUN1/GLUN2A lbd in complex with GNE0723 | x-ray diffraction | A | 6RV | — |
| 5TP9 | Structure of the human GLUN1/GLUN2A lbd in complex with compound 2 (GNE9178) | x-ray diffraction | A | 7H0 | — |
| 5TPA | Structure of the human GLUN1/GLUN2A lbd in complex with compound 9 (GNE3500) | x-ray diffraction | A | 7H2 | — |
| 6IRA | Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 7.8 | electron microscopy | D, B | — | — |
| 6IRA | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLUTAMATE/GLYCINE-bound state at pH 7.8 | electron microscopy | D, B | — | — |
| 6IRF | Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3… | electron microscopy | B, D | — | — |
| 6IRF | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLUTAMATE/GLYCINE-bound state at pH 6.3… | electron microscopy | B, D | — | — |
| 6IRG | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLUTAMATE/GLYCINE-bound state at pH 6.3… | electron microscopy | B, D | — | — |
| 6IRH | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLUTAMATE/GLYCINE-bound state at pH 6.3… | electron microscopy | D, B | — | — |
| 7EOQ | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLYCINE/CPP bound state | electron microscopy | A, C | NAG, 7RC | — |
| 7EOR | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLYCINE/GLUTAMATE/GNE-6901 bound state | electron microscopy | A, C | NAG, 6RM | — |
| 7EOS | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLYCINE/GLUTAMATE bound state | electron microscopy | A, C | NAG | — |
| 7EOT | Structure of the human GLUN1/GLUN2A NMDA receptor in the cgp- 78608/GLUTAMATE bound state | electron microscopy | A, C | NAG | — |
| 7EOU | Structure of the human GLUN1/GLUN2A NMDA receptor in the GLYCINE/GLUTAMATE/GNE-6901/9-aa bound state | electron microscopy | A, C | NAG, 6RM | — |
| 7EU7 | Structure of the human GluN1-GluN2A NMDA receptor in complex with S-ketamine, glycine and glutamate | electron microscopy | B, D | NAG, JC9 | — |
| 7EU7 | Structure of the human GLUN1-GLUN2A NMDA receptor in complex with S- ketamine, glycine and glutamate | electron microscopy | B, D | NAG, JC9 | — |
| 8JIZ | Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation | electron microscopy | A, C | NAG | 18 (best 0.87) |
| 8VUR | Human GluN1-2A with IgG 003-102 WT conformation | electron microscopy | B, D | — | 14 (best 0.85) |
| Q12879 | AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2A (Q12879) | — | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 8 records
- 6RM · 7-[(4-fluoranylphenoxy)methyl]-3-[(1~{R},2~{R})-2-(hydroxymethyl)cyclopropyl]-2-methyl-[1,3]thiazolo[3, 2-a]pyrimidin-5-one · in 4 records
- GLU · Glutamic acid · in 3 records
- 6RV · (1~{R},2~{R})-2-[7-[[5-chloranyl-3-(trifluoromethyl) pyrazol-1-yl]methyl]-5-oxidanylidene-2-(trifluoromethyl)-[1,3]thiazolo[3,2-a]pyrimidin-3-yl]cyclopropane-1-carbonitrile · in 2 records
- JC9 · (2~{S})-2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one · in 2 records
- 5YD · 4-[[(4-fluorophenyl)sulfonylamino]methyl]-~{N}-(pyridin-3-ylmethyl)benzamide · in 1 record
- 5YE · 6-[[ethyl-(4-fluorophenyl)amino]methyl]-2,3-dihydro-1~{H}-cyclopenta[3,4][1,3]thiazolo[1,4-~{a}]pyrimidin-8-one · in 1 record
- 67H · 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide · in 1 record
- 7H0 · 7-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-N-ethyl-2-methyl-5-oxo-5H-[1,3]thiazolo[3, 2-a]pyrimidine-3-carboxamide · in 1 record
- 7H2 · (1R,2R)-2-(2-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-7-methyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropane-1-carbonitrile · in 1 record
- 7RC · (2R)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid · in 1 record
Elsewhere
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