Research workbench
Molecular basis for protein recognition specificity of the DYNLT1/TCTEX1 canonical binding groove. characterization of the interaction with activin receptor iib
Analyse Molecular basis for protein recognition specificity of the DYNLT1/TCTEX1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5JPW
- Type
- protein
- Length
- 286 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dynein light chain tctex-type 1,CYTOPLASMIC dynein 1 intermediate chain 2
- UniProt
- P63172, Q13409
- Pockets
- 10 · best druggability 0.68
Structure
solution nmr · 1 distinct chain · 27% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Dynein light chain tctex-type 1,CYTOPLASMIC dynein 1 intermediate chain 2 | protein | 143 | 27% helix, 26% strand | P63172, Q13409 |
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 58 | 0.68 | 0.96 | 20 | empty |
| 2 | 111 | 0.68 | 0.90 | 31 | empty |
| 3 | 335 | 0.63 | 0.79 | 55 | empty |
| 4 | 98 | 0.56 | 0.85 | 25 | empty |
| 5 | 90 | 0.56 | 0.86 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 1150 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 5JPW · Molecular basis for protein recognition specificity of the DYNLT1/Tctex1 canonical… · the same entry in another collection · chain A against A, TM-score 1.00
- P63172 · AlphaFold monomer V2.0 prediction for dynein light chain tctex-type 1 (P63172) · a predicted model of the same protein · chain B against A, TM-score 0.50
- Q13409 · AlphaFold monomer V2.0 prediction for cytoplasmic dynein 1 intermediate chain 2 (Q13409) · a predicted model of the same protein · chain A against A, TM-score 0.31
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63172
- Every structure of UniProt Q13409
- Elsewhere: RCSB PDB 5JPW · PDBe 5JPW · UniProt P63172 · UniProt Q13409
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