UniProt Q13409
Cytoplasmic dynein 1 intermediate chain 2 (Q13409)
Cytoplasmic dynein 1 intermediate chain 2 (UniProt Q13409): 24 experimental structures and 1 predicted model on GenesisL1, 116 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q13409
- Protein
- Cytoplasmic dynein 1 intermediate chain 2
- Experimental structures
- 24
- Predicted models
- 1
- Pockets
- 116 · 19 records with a druggable one
Structures
25 records of Q13409 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5JPW | Molecular basis for protein recognition specificity of the DYNLT1/Tctex1 canonical binding groove.… | solution nmr | A, B | — | 10 (best 0.68) |
| 5JPW | Molecular basis for protein recognition specificity of the DYNLT1/TCTEX1 canonical binding groove.… | solution nmr | A, B | — | 10 (best 0.68) |
| 6F1T | Cryo-EM structure of two dynein tail domains bound to dynactin and BICDR1 | electron microscopy | g, h, o, p | — | 4 (best 0.85) |
| 6F1T | Cryo-EM structure of two dynein tail domains bound to dynactin and BICDR1 | electron microscopy | g, h, o, p | — | 4 (best 0.85) |
| 6F1U | N terminal region of dynein tail domains in complex with dynactin filament and BICDR-1 | electron microscopy | h | — | 4 (best 0.79) |
| 6F1U | N terminal region of dynein tail domains in complex with dynactin filament and bicdr-1 | electron microscopy | h | — | 4 (best 0.79) |
| 6F1Z | Roadblock-1 region of the dynein tail/dynactin/BICDR1 complex | electron microscopy | o, p | — | 4 (best 0.73) |
| 6F1Z | Roadblock-1 region of the dynein TAIL/DYNACTIN/BICDR1 complex | electron microscopy | o, p | — | 4 (best 0.73) |
| 6F38 | Cryo-EM structure of two dynein tail domains bound to dynactin and HOOK3 | electron microscopy | g, h, o, p | — | 4 (best 0.81) |
| 6F38 | Cryo-EM structure of two dynein tail domains bound to dynactin and HOOK3 | electron microscopy | g, h, o, p | — | 4 (best 0.81) |
| 6F3A | Cryo-EM structure of a single dynein tail domain bound to dynactin and BICD2N | electron microscopy | g, h | — | 2 (best 0.86) |
| 7Z8F | Composite structure of dynein-dynactin-BICDR on microtubules | electron microscopy | g, h, o, p | — | 3 (best 0.71) |
| 7Z8I | The barbed end complex of dynactin bound to BICDR1 and the cytoplasmic dynein tails (A2, B1, B2) | electron microscopy | h, o | — | — |
| 7Z8J | Cytoplasmic dynein (A2) bound to BICDR1 | electron microscopy | h, o | — | 14 (best 0.76) |
| 7Z8J | Cytoplasmic dynein (A2) bound to BICDR1 | electron microscopy | h, o | — | — |
| 7Z8K | Cytoplasmic dynein (A1) bound to BICDR1 | electron microscopy | h | — | 7 (best 0.81) |
| 7Z8K | Cytoplasmic dynein (A1) bound to BICDR1 | electron microscopy | h | — | — |
| 8PQW | Cytoplasmic dynein-1 motor domain bound to dynactin-p150glued and LIS1 | electron microscopy | H, I | — | — |
| 8PQZ | Cytoplasmic dynein-1 A1/A2 motor domains bound to LIS1 | electron microscopy | H, I | — | — |
| 8PR0 | Cytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC tower | electron microscopy | D, C | — | 6 (best 0.81) |
| 8PR1 | Cytoplasmic dynein-B heavy chain bound to IC-LC tower | electron microscopy | I, J | — | 12 (best 0.83) |
| 8PR2 | Cytoplasmic dynein-1 heavy chain bound to JIP3-LZI | electron microscopy | h | — | 6 (best 0.80) |
| 8PR3 | Cytoplasmic dynein-1 heavy chain bound to JIP3-RH1 | electron microscopy | h, o | — | 12 (best 0.77) |
| 8PTK | Composite structure of Dynein-Dynactin-JIP3-LIS1 | electron microscopy | g, h, o, p | — | 2 (best 0.81) |
| Q13409 | AlphaFold monomer V2.0 prediction for cytoplasmic dynein 1 intermediate chain 2 (Q13409) | predicted | A | — | — |
Experiment against prediction
- 7Z8J chain h against the predicted model Q13409: TM-score 0.99, RMSD 0.63 Å
- 7Z8J chain h against the predicted model Q13409: TM-score 0.99, RMSD 0.63 Å
- 7Z8I chain o against the predicted model Q13409: TM-score 0.99, RMSD 0.64 Å
- 7Z8J chain o against the predicted model Q13409: TM-score 0.99, RMSD 0.66 Å
- 7Z8J chain o against the predicted model Q13409: TM-score 0.99, RMSD 0.66 Å
- 7Z8K chain h against the predicted model Q13409: TM-score 0.99, RMSD 0.67 Å
- 7Z8K chain h against the predicted model Q13409: TM-score 0.99, RMSD 0.67 Å
- 7Z8I chain h against the predicted model Q13409: TM-score 0.99, RMSD 0.68 Å
- 8PR3 chain o against the predicted model Q13409: TM-score 0.99, RMSD 0.78 Å
- 8PR3 chain h against the predicted model Q13409: TM-score 0.99, RMSD 0.80 Å
Elsewhere
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