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Crystal structure of the signaling protein complex 5

Analyse Crystal structure of the signaling protein complex 5 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5IXZ
Type: protein
Length: 364 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ALR2278 protein
UniProt: Q8YUQ7
Ligands: HEM
Pockets: 4 · best druggability 0.84

Structure

x-ray diffraction · 1 distinct chain · 53% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	ALR2278 protein	protein	182	53% helix, 16% strand	Q8YUQ7

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
DMS · Dimethyl sulfoxide · additive · 2 copies · chains A, B
MLI · Malonate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	352	0.84	0.93	37	HEM, DMS
2	579	0.83	0.88	82	HEM, DMS, MLI
3	218	0.57	0.79	26	empty
4	132	0.55	0.82	35	empty

Interfaces

1 interface between chains.

A–B · 1107 Å² buried · 8 hydrogen bonds · protein-protein

Compared structures

5IXZ · Crystal structure of the signaling protein complex 5 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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Every structure of UniProt Q8YUQ7
Elsewhere: RCSB PDB 5IXZ · PDBe 5IXZ · UniProt Q8YUQ7

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