Research workbench
Crystal structural of the METTL3-METTL14 complex for N6-adenosine methylation
Analyse Crystal structural of the METTL3-METTL14 complex for N6-adenosine methylation in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5IL0
- Type
- protein
- Length
- 493 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- METTL3; METTL14
- EC
- 2.1.1.62
- UniProt
- Q86U44, Q9HCE5
- Ligands
- BR
- Pockets
- 7 · best druggability 0.64
Structure
x-ray diffraction · 2 distinct chains · 26% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | METTL3 (EC 2.1.1.62) | protein | 211 | 22% helix, 27% strand | Q86U44 |
| B | METTL14 (EC 2.1.1.62) | protein | 282 | 28% helix, 23% strand | Q9HCE5 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 262 | 0.64 | 0.82 | 28 | empty |
| 2 | 380 | 0.63 | 0.78 | 54 | empty |
| 3 | 65 | 0.49 | 0.84 | 16 | empty |
| 4 | 53 | 0.41 | 0.82 | 17 | EDO |
| 5 | 54 | 0.40 | 0.81 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 2526 Ų buried · 45 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 5IL0 · Crystal structural of the METTL3-METTL14 complex for N6-adenosine methylation · the same entry in another collection · chain A against A, TM-score 1.00
- Q9HCE5 · AlphaFold monomer V2.0 prediction for N6-adenosine-methyltransferase non-catalytic… · a predicted model of the same protein · chain B against A, TM-score 0.99
- Q86U44 · AlphaFold monomer V2.0 prediction for N6-adenosine-methyltransferase catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86U44
- Every structure of UniProt Q9HCE5
- Elsewhere: RCSB PDB 5IL0 · PDBe 5IL0 · UniProt Q86U44 · UniProt Q9HCE5
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