Research workbench
Laminin A2LG45 C-form, G6/7 bound.
Analyse Laminin A2LG45 C-form, G6/7 bound. in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5IK5
- Type
- protein
- Length
- 379 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Laminin subunit alpha-2
- UniProt
- Q60675
- Ligands
- 4MU, NAG, BDP, XYS, A2G, GAL, CA
- Pockets
- 2 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 2% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Laminin subunit alpha-2 | protein | 379 | 2% helix, 50% strand | Q60675 |
Ligands and binding sites
- 4MU · 7-hydroxy-4-methyl-2H-chromen-2-one · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A
- BDP · beta-D-glucopyranuronic acid · sugar · 2 copies · chains A
- XYS · alpha-D-xylopyranose · sugar · 2 copies · chains A
- A2G · 2-acetamido-2-deoxy-alpha-D-galactopyranose · sugar · chains A
- GAL · beta-D-galactopyranose · sugar
- CA · Calcium ion · metal · 2 copies · chains A
- GOL · Glycerol · additive · 6 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 107 | 0.53 | 0.83 | 18 | empty |
| 2 | 182 | 0.47 | 0.76 | 24 | empty |
Modifications
Observed in the structure: 3 disulfide, 2 glycan (disulfide, N-glycosylation, O-glycosylation).
Compared structures
- 5IK5 · Laminin A2LG45 C-form, G6/7 bound. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q60675
- Elsewhere: RCSB PDB 5IK5 · PDBe 5IK5 · UniProt Q60675
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