Research workbench

Macrolide 2'-phosphotransferase type II - complex with GDP and azithromycin

Analyse Macrolide 2'-phosphotransferase type II - complex with GDP and azithromycin in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5IGV
Type: protein
Length: 298 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Macrolide 2'-phosphotransferase II
UniProt: O32553
Ligands: GDP, ZIT, MG, CA
Pockets: 1 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Macrolide 2'-phosphotransferase II	protein	298	48% helix, 16% strand	O32553

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · chains A
ZIT · Azithromycin · ligand · chains A
MG · Magnesium ion · metal · chains A
CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1064	0.74	0.77	83	MG, CA, GDP, ZIT

Compared structures

5IGV · Macrolide 2'-phosphotransferase type II - complex with GDP and azithromycin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O32553
Elsewhere: RCSB PDB 5IGV · PDBe 5IGV · UniProt O32553

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.