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Macrolide 2'-phosphotransferase type I - complex with guanosine and clarithromycin

Analyse Macrolide 2'-phosphotransferase type I - complex with guanosine and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5IGJ
Type: protein
Length: 300 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Macrolide 2'-phosphotransferase
UniProt: Q47396
Ligands: GMP, CTY
Pockets: 1 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Macrolide 2'-phosphotransferase	protein	300	48% helix, 17% strand	Q47396

Ligands and binding sites

GMP · Guanosine · ligand · chains A
CTY · Clarithromycin · ligand · chains A
IPA · Isopropyl alcohol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1187	0.73	0.76	76	GMP, CTY

Compared structures

5IGJ · Macrolide 2'-phosphotransferase type I - complex with guanosine and clarithromycin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q47396
Elsewhere: RCSB PDB 5IGJ · PDBe 5IGJ · UniProt Q47396

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