Research workbench
Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef)
Analyse Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1K8T
- Type
- protein
- Length
- 498 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin-sensitive adenylate cyclase
- EC
- 4.6.1.1
- UniProt
- P40136
- Ligands
- NI, SO4
- Pockets
- 7 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin-sensitive adenylate cyclase (EC 4.6.1.1) | protein | 498 | 43% helix, 15% strand | P40136 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 456 | 0.67 | 0.79 | 44 | empty |
| 2 | 127 | 0.46 | 0.78 | 24 | empty |
| 3 | 167 | 0.44 | 0.75 | 21 | SO4, NI |
| 4 | 94 | 0.44 | 0.79 | 19 | empty |
| 5 | 73 | 0.39 | 0.78 | 16 | SO4 |
Compared structures
- 1K8T · Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) · the same entry in another collection · chain A against A, TM-score 1.00
- P40136 · AlphaFold monomer V2.0 prediction for calmodulin-sensitive adenylate cyclase (P40136) · a predicted model of the same protein · chain A against A, TM-score 0.68
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P40136
- Elsewhere: RCSB PDB 1K8T · PDBe 1K8T · UniProt P40136
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