UniProt P40136
Calmodulin-sensitive adenylate cyclase (P40136)
Calmodulin-sensitive adenylate cyclase (UniProt P40136), EC 4.6.1.1: 35 experimental structures and 1 predicted model on GenesisL1, 17 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P40136
- Protein
- Calmodulin-sensitive adenylate cyclase
- EC
- 4.6.1.1
- Experimental structures
- 35
- Predicted models
- 1
- Pockets
- 17 · 3 records with a druggable one
Structures
36 records of P40136 in the MolNFT archive: 35 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1K8T | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) | x-ray diffraction | A | — | — |
| 1K8T | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) | x-ray diffraction | A | — | — |
| 1K90 | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with… | x-ray diffraction | A, B, C | — | — |
| 1K90 | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with… | x-ray diffraction | A, B, C | — | — |
| 1K93 | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with… | x-ray diffraction | A, B, C | — | — |
| 1K93 | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with… | x-ray diffraction | A, B, C | — | — |
| 1LVC | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with… | x-ray diffraction | A, B, C | — | — |
| 1LVC | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with… | x-ray diffraction | A, B, C | — | — |
| 1PK0 | Crystal Structure of the EF3-CaM complexed with PMEApp | x-ray diffraction | A, B, C | — | — |
| 1PK0 | Crystal structure of the EF3-cam complexed with pmeapp | x-ray diffraction | A, B, C | — | — |
| 1S26 | Structure of Anthrax Edema Factor-Calmodulin-alpha,beta-methyleneadenosine 5'-triphosphate Complex… | x-ray diffraction | A, B, C | — | — |
| 1S26 | Structure of anthrax edema factor-calmodulin-ALPHA,BETA- methyleneadenosine 5'-triphosphate complex… | x-ray diffraction | A, B, C | — | — |
| 1SK6 | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with… | x-ray diffraction | A, B, C | — | — |
| 1SK6 | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (ef) in complex with… | x-ray diffraction | A, B, C | — | — |
| 1XFU | Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1XFU | Crystal structure of anthrax edema factor (ef) truncation mutant, ef- delta 64 in complex with… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1XFV | Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1XFV | Crystal structure of anthrax edema factor (ef) in complex with calmodulin and 3' deoxy-ATP | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1XFW | Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3'5' cyclic AMP (cAMP) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1XFW | Crystal structure of anthrax edema factor (ef) in complex with calmodulin and 3'5' cyclic AMP (camp) | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1XFX | Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 10… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1XFX | Crystal structure of anthrax edema factor (ef) in complex with calmodulin in the presence of 10… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1XFY | Crystal structure of anthrax edema factor (EF) in complex with calmodulin | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1XFY | Crystal structure of anthrax edema factor (ef) in complex with calmodulin | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1XFZ | Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1XFZ | Crystal structure of anthrax edema factor (ef) in complex with calmodulin in the presence of 1… | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1Y0V | Crystal structure of anthrax edema factor (EF) in complex with calmodulin and pyrophosphate | x-ray diffraction | A, B, C, D, E, F | — | — |
| 1Y0V | Crystal structure of anthrax edema factor (ef) in complex with calmodulin and pyrophosphate | x-ray diffraction | A, B, C, D, E, F | — | — |
| 6UZB | Anthrax toxin protective antigen channels bound to edema factor | electron microscopy | H | — | 4 (best 0.78) |
| 6UZB | Anthrax toxin protective antigen channels bound to edema factor | electron microscopy | H | — | — |
| 6UZD | Anthrax toxin protective antigen channels bound to edema factor | electron microscopy | H, I | — | 6 (best 0.81) |
| 6UZD | Anthrax toxin protective antigen channels bound to edema factor | electron microscopy | H, I | — | — |
| 6UZE | Anthrax toxin protective antigen channels bound to edema factor | electron microscopy | H, I | — | 7 (best 0.80) |
| 6UZE | Anthrax toxin protective antigen channels bound to edema factor | electron microscopy | H, I | — | — |
| 6VRA | Anthrax octamer prechannel bound to full-length edema factor | electron microscopy | I, J, K, L | — | — |
| P40136 | AlphaFold monomer V2.0 prediction for calmodulin-sensitive adenylate cyclase (P40136) | predicted | A | — | — |
Experiment against prediction
- 1XFZ chain E against the predicted model P40136: TM-score 0.97, RMSD 1.57 Å
- 1XFZ chain E against the predicted model P40136: TM-score 0.97, RMSD 1.57 Å
- 1XFZ chain D against the predicted model P40136: TM-score 0.97, RMSD 1.58 Å
- 1XFZ chain D against the predicted model P40136: TM-score 0.97, RMSD 1.58 Å
- 1XFZ chain F against the predicted model P40136: TM-score 0.97, RMSD 1.58 Å
- 1XFZ chain F against the predicted model P40136: TM-score 0.97, RMSD 1.58 Å
- 1XFZ chain B against the predicted model P40136: TM-score 0.97, RMSD 1.58 Å
- 1XFZ chain B against the predicted model P40136: TM-score 0.97, RMSD 1.58 Å
- 1XFU chain B against the predicted model P40136: TM-score 0.97, RMSD 1.58 Å
- 1XFU chain B against the predicted model P40136: TM-score 0.97, RMSD 1.58 Å
Elsewhere
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