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Crystal structure of SIAH2 sbd domain
Analyse Crystal structure of SIAH2 sbd domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5H9M
- Type
- protein
- Length
- 379 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- E3 ubiquitin-protein ligase SIAH2
- EC
- 6.3.2.-
- UniProt
- O43255
- Ligands
- ZN, UNX, CL
- Pockets
- 2 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 21% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase SIAH2 (EC 6.3.2.-) | protein | 190 | 21% helix, 43% strand | O43255 |
| B | E3 ubiquitin-protein ligase SIAH2 (EC 6.3.2.-) | protein | 189 | 20% helix, 43% strand | O43255 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B
- UNX · Unknown atom or ion · ion · 4 copies · chains A, B
- CL · Chloride ion · ion · 3 copies · chains A, B
- 1PE · Pentaethylene glycol · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.38 | 0.79 | 17 | empty |
| 2 | 84 | 0.37 | 0.77 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1063 Ų buried · 16 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O43255
- Elsewhere: RCSB PDB 5H9M · PDBe 5H9M · UniProt O43255
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