MolNFT v1 · #428605 · protein

AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase SIAH2 (O43255)

O43255: “AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase SIAH2 (O43255)”. 2 pockets (best druggability 0.41). MolNFT v1 #428605 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

Accession: O43255
Type: protein
Length: 324 residues
Chains: 1
Collection: MolNFT v1 / AlphaFold
Contract: 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
Owner: 0x4Ef77Afb5a3D9F41c95Be3227D1CC986CCb61835
Molecule: E3 ubiquitin-protein ligase SIAH2
UniProt: O43255
Pockets: 2 · best druggability 0.41

Structure

1 distinct chain · 17% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	E3 ubiquitin-protein ligase SIAH2	protein	324	17% helix, 30% strand	O43255

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	148	0.41	0.74	26	empty
2	81	0.33	0.74	14	empty

Compared structures

5H9M · Crystal structure of siah2 SBD domain · an experimental structure of the same protein · chain A against B, TM-score 0.53
5H9M · Crystal structure of SIAH2 sbd domain · an experimental structure of the same protein · chain A against B, TM-score 0.53

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O43255
Elsewhere: UniProt O43255 · AlphaFold DB O43255

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