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The structure of mini-MFN1 K88A in complex with GDP

Analyse The structure of mini-MFN1 K88A in complex with GDP in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5GNR
Type: protein
Length: 387 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mitofusin-1
EC: 3.6.5.-
UniProt: Q8IWA4
Ligands: GDP
Pockets: 4 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 56% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mitofusin-1 (EC 3.6.5.-)	protein	387	56% helix, 12% strand	Q8IWA4

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	107	0.51	0.82	22	empty
2	132	0.49	0.79	32	GDP
3	73	0.35	0.76	14	empty
4	52	0.26	0.73	12	empty

Compared structures

5GNR · the structure of mini-MFN1 K88A in complex with GDP · the same entry in another collection · chain A against A, TM-score 1.00
Q8IWA4 · AlphaFold monomer V2.0 prediction for mitofusin-1 (Q8IWA4) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8IWA4
Elsewhere: RCSB PDB 5GNR · PDBe 5GNR · UniProt Q8IWA4

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