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Structural basis for recognition of the intron branch site RNA by splicing factor 1

Analyse Structural basis for recognition of the intron branch site RNA by splicing… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
1K1G
Type
protein + RNA
Length
133 residues
Chains
2
Method
solution nmr
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
5'-R(*UP*AP*UP*AP*CP*UP*AP*AP*CP*AP*A)-3'; SF1-bo isoform
UniProt
Q15637

Structure

solution nmr · 2 distinct chains · 38% helix, 16% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
B5'-R(*UP*AP*UP*AP*CP*UP*AP*AP*CP*AP*A)-3'rna11——
ASF1-bo isoformprotein12238% helix, 16% strandQ15637

Interfaces

1 interface between chains.

  • B–A · 1190 Ų buried · 26 hydrogen bonds · protein-nucleic

Compared structures

  • 1K1G · Structural basis for recognition of the intron branch site RNA by splicing factor 1 · the same entry in another collection · chain B against B, TM-score 1.00
  • Q15637 · AlphaFold monomer V2.0 prediction for splicing factor 1 (Q15637) · a predicted model of the same protein · chain A against A, TM-score 0.74

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