MolNFT v1 · #427026 · protein
AlphaFold monomer V2.0 prediction for splicing factor 1 (Q15637)
Q15637: “AlphaFold monomer V2.0 prediction for splicing factor 1 (Q15637)”. 4 pockets (best druggability 0.45). MolNFT v1 #427026 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q15637
- Type
- protein
- Length
- 639 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x9188600a0FCa2914254C94299b1bd9721Bc4D500
- Molecule
- Splicing factor 1
- UniProt
- Q15637
- Pockets
- 4 · best druggability 0.45
Structure
1 distinct chain · 21% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Splicing factor 1 | protein | 639 | 21% helix, 3% strand | Q15637 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 146 | 0.45 | 0.76 | 19 | empty |
| 2 | 61 | 0.35 | 0.78 | 17 | empty |
| 3 | 95 | 0.34 | 0.73 | 21 | empty |
| 4 | 70 | 0.29 | 0.73 | 17 | empty |
Compared structures
- 1K1G · Structural basis for recognition of the intron branch site RNA by splicing factor 1 · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 1K1G · Structural basis for recognition of the intron branch site RNA by splicing factor 1 · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 4FXW · Structure of phosphorylated SF1 complex with U2AF65-uhm domain · an experimental structure of the same protein · chain A against D, TM-score 0.16
- 4FXW · Structure of phosphorylated SF1 complex with U2AF65-UHM domain · an experimental structure of the same protein · chain A against D, TM-score 0.16
- 2M0G · Structure, phosphorylation and U2AF65 binding of the Nterminal Domain of splicing factor… · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 2M0G · Structure, phosphorylation and U2AF65 binding of the nterminal domain of splicing factor… · an experimental structure of the same protein · chain A against A, TM-score 0.16
- 2M09 · Structure, phosphorylation and U2AF65 binding of the nterminal domain of splicing factor… · an experimental structure of the same protein · chain A against A, TM-score 0.15
- 2M09 · Structure, phosphorylation and U2AF65 binding of the Nterminal Domain of splicing factor… · an experimental structure of the same protein · chain A against A, TM-score 0.15
- 4FXX · Structure of SF1 coiled-coil domain · an experimental structure of the same protein · chain A against A, TM-score 0.14
- 4FXX · Structure of SF1 coiled-coil domain · an experimental structure of the same protein · chain A against A, TM-score 0.14
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15637
- Elsewhere: UniProt Q15637 · AlphaFold DB Q15637
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