Human notch 1, EGF 4-7

Structure

x-ray diffraction · 2 distinct chains · 5% helix, 30% strand (DSSP).

Ligands and binding sites

• CA · Calcium ion · metal · 5 copies · chains A, B
• CL · Chloride ion · ion · 2 copies · chains B
• EDO · 1,2-ethanediol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 530 Ų buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 24 disulfide (disulfide).

Compared structures

• 5FMA · human Notch 1, EGF 4-7 · the same entry in another collection · chain A against A, TM-score 1.00
• P46531 · AlphaFold monomer V2.0 prediction for neurogenic locus notch homolog protein 1 (P46531) · a predicted model of the same protein · chain B against A, TM-score 0.61

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P46531
• Elsewhere: RCSB PDB 5FMA · PDBe 5FMA · UniProt P46531