A. thaliana IGPD2 in complex with the triazole-phosphonate inhibitor, (R)-C348, to 1.36A resolution

Structure

x-ray diffraction · 1 distinct chain · 33% helix, 31% strand (DSSP).

Ligands and binding sites

• 5LD · [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid · ligand · chains A
• MN · Manganese (II) ion · metal · 2 copies
• CL · Chloride ion · ion · chains A
• EDO · 1,2-ethanediol · additive · 2 copies · chains A
• TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5ELW · A. thaliana IGPD2 in complex with the triazole-phosphonate inhibitor, (R)-C348, to 1.36A… · the same entry in another collection · chain A against A, TM-score 1.00
• O23346 · AlphaFold monomer V2.0 prediction for imidazoleglycerol-phosphate dehydratase 2… · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O23346
• Elsewhere: RCSB PDB 5ELW · PDBe 5ELW · UniProt O23346