UniProt O23346
Imidazoleglycerol-phosphate dehydratase 2, chloroplastic (O23346)
Imidazoleglycerol-phosphate dehydratase 2, chloroplastic (UniProt O23346), EC 4.2.1.19: 20 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 20 pockets. Binding sites, druggability and experiment…
- UniProt
- O23346
- Protein
- Imidazoleglycerol-phosphate dehydratase 2, chloroplastic
- EC
- 4.2.1.19
- Experimental structures
- 20
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 20 · 1 record with a druggable one
Structures
21 records of O23346 in the MolNFT archive: 20 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4MU0 | The structure of wt A. thaliana IGPD2 in complex with Mn2+ and 1,2,4-triazole at 1.3 A resolution | x-ray diffraction | A | — | — |
| 4MU0 | The structure of wt a. thaliana IGPD2 in complex with MN2+ and 1,2,4- triazole at 1.3 a resolution | x-ray diffraction | A | — | — |
| 4MU1 | The structure of wt A. thaliana IGPD2 in complex with Mn2+, imidazole, and sulfate at 1.5 A… | x-ray diffraction | A | — | — |
| 4MU1 | The structure of wt a. thaliana IGPD2 in complex with MN2+, imidazole, and sulfate at 1.5 a… | x-ray diffraction | A | — | — |
| 4MU3 | The form A structure of an E21Q catalytic mutant of A. thaliana IGPD2 in complex with Mn2+ and a… | x-ray diffraction | A | — | — |
| 4MU3 | The form a structure of an E21Q catalytic mutant of a. thaliana IGPD2 in complex with MN2+ and a… | x-ray diffraction | A | — | — |
| 4MU4 | The form B structure of an E21Q catalytic mutant of A. thaliana IGPD2 in complex with Mn2+ and its… | x-ray diffraction | A | — | — |
| 4MU4 | The form B structure of an E21Q catalytic mutant of a. thaliana IGPD2 in complex with MN2+ and its… | x-ray diffraction | A | — | — |
| 4QNJ | The structure of wt A. thaliana IGPD2 in complex with Mn2+ and formate at 1.3A resolution | x-ray diffraction | A | — | — |
| 4QNJ | The structure of wt a. thaliana IGPD2 in complex with MN2+ and formate at 1.3A resolution | x-ray diffraction | A | — | — |
| 4QNK | The structure of wt A. thaliana IGPD2 in complex with Mn2+ and phosphate | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 4QNK | The structure of wt a. thaliana IGPD2 in complex with MN2+ and phosphate | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5EKW | A. thaliana IGPD2 in complex with the racemate of the triazole-phosphonate inhibitor, C348 | x-ray diffraction | A | 5DL, 5LD, CL | — |
| 5EKW | A. thaliana IGPD2 in complex with the racemate of the triazole- phosphonate inhibitor, C348 | x-ray diffraction | A | — | — |
| 5EL9 | A. thaliana IGPD2 in complex with the triazole-phosphonate inhibitor, (S)-C348, to 1.1A resolution | x-ray diffraction | A | 5DL | — |
| 5EL9 | A. thaliana IGPD2 in complex with the triazole-phosphonate inhibitor, (S)-C348, to 1.1A resolution | x-ray diffraction | A | — | — |
| 5ELW | A. thaliana IGPD2 in complex with the triazole-phosphonate inhibitor, (R)-C348, to 1.36A resolution | x-ray diffraction | A | 5LD, CL | — |
| 5ELW | A. thaliana IGPD2 in complex with the triazole-phosphonate inhibitor, (R)-C348, to 1.36A resolution | x-ray diffraction | A | — | — |
| 6EZJ | Imidazoleglycerol-phosphate dehydratase | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | MN, 5LD | 20 (best 0.74) |
| 6EZJ | Imidazoleglycerol-phosphate dehydratase | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X | MN, 5LD | — |
| O23346 | AlphaFold monomer V2.0 prediction for imidazoleglycerol-phosphate dehydratase 2, chloroplastic… | predicted | A | — | — |
Ligands
Experiment against prediction
- 5EKW chain A against the predicted model O23346: TM-score 1.00, RMSD 0.22 Å
- 5EKW chain A against the predicted model O23346: TM-score 1.00, RMSD 0.22 Å
- 5EL9 chain A against the predicted model O23346: TM-score 1.00, RMSD 0.22 Å
- 5EL9 chain A against the predicted model O23346: TM-score 1.00, RMSD 0.22 Å
- 4MU4 chain A against the predicted model O23346: TM-score 1.00, RMSD 0.22 Å
- 4MU4 chain A against the predicted model O23346: TM-score 1.00, RMSD 0.22 Å
- 5ELW chain A against the predicted model O23346: TM-score 1.00, RMSD 0.24 Å
- 5ELW chain A against the predicted model O23346: TM-score 1.00, RMSD 0.24 Å
- 4MU0 chain A against the predicted model O23346: TM-score 1.00, RMSD 0.25 Å
- 4MU0 chain A against the predicted model O23346: TM-score 1.00, RMSD 0.25 Å
Elsewhere
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