Research workbench
Structure of CFBRCC36-CFKIAA0157 complex (qsq mutant)
Analyse Structure of CFBRCC36-CFKIAA0157 complex (qsq mutant) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5CW5
- Type
- protein
- Length
- 900 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BRCA1/BRCA2-containing complex subunit 3; Protein FAM175B
- UniProt
- E2AXC7, E2AB17
- Pockets
- 13 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 44% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | BRCA1/BRCA2-containing complex subunit 3 | protein | 217 | 47% helix, 29% strand | E2AXC7 |
| B | Protein FAM175B | protein | 229 | 42% helix, 31% strand | E2AB17 |
| C | BRCA1/BRCA2-containing complex subunit 3 | protein | 214 | 47% helix, 28% strand | E2AXC7 |
| D | Protein FAM175B | protein | 240 | 41% helix, 30% strand | E2AB17 |
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 541 | 0.76 | 0.83 | 54 | empty |
| 2 | 496 | 0.75 | 0.83 | 49 | empty |
| 3 | 734 | 0.72 | 0.78 | 70 | empty |
| 4 | 52 | 0.62 | 0.93 | 20 | empty |
| 5 | 51 | 0.60 | 0.93 | 17 | empty |
Interfaces
5 interfaces between chains.
- A–B · 4075 Ų buried · 47 hydrogen bonds · protein-protein
- C–D · 4050 Ų buried · 54 hydrogen bonds · protein-protein
- A–C · 611 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 588 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 567 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 5CW5 · Structure of CfBRCC36-CfKIAA0157 complex (QSQ mutant) · the same entry in another collection · chain D against D, TM-score 1.00
- E2AB17 · AlphaFold monomer V2.0 prediction for brisc complex subunit FAM175B (E2AB17) · a predicted model of the same protein · chain B against A, TM-score 0.99
- E2AXC7 · AlphaFold monomer V2.0 prediction for lys-63-specific deubiquitinase BRCC36 (E2AXC7) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E2AXC7
- Every structure of UniProt E2AB17
- Elsewhere: RCSB PDB 5CW5 · PDBe 5CW5 · UniProt E2AXC7 · UniProt E2AB17
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