Research workbench
Structure of CFBRCC36-CFKIAA0157 complex (zn edge)
Analyse Structure of CFBRCC36-CFKIAA0157 complex (zn edge) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5CW3
- Type
- protein
- Length
- 978 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BRCA1/BRCA2-containing complex subunit 3; Protein FAM175B
- UniProt
- E2AXC7, E2AB17
- Ligands
- ZN
- Pockets
- 15 · best druggability 0.78
Structure
x-ray diffraction · 4 distinct chains · 45% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | BRCA1/BRCA2-containing complex subunit 3 | protein | 248 | 48% helix, 23% strand | E2AXC7 |
| B | Protein FAM175B | protein | 250 | 40% helix, 30% strand | E2AB17 |
| C | BRCA1/BRCA2-containing complex subunit 3 | protein | 239 | 49% helix, 24% strand | E2AXC7 |
| D | Protein FAM175B | protein | 241 | 42% helix, 30% strand | E2AB17 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 631 | 0.78 | 0.84 | 58 | empty |
| 2 | 640 | 0.77 | 0.83 | 63 | empty |
| 3 | 448 | 0.69 | 0.80 | 44 | empty |
| 4 | 483 | 0.68 | 0.79 | 42 | empty |
| 5 | 329 | 0.59 | 0.77 | 35 | empty |
Interfaces
5 interfaces between chains.
- A–B · 4147 Ų buried · 48 hydrogen bonds · protein-protein
- C–D · 4070 Ų buried · 41 hydrogen bonds · protein-protein
- A–C · 618 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 607 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 569 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 5CW3 · Structure of CfBRCC36-CfKIAA0157 complex (Zn Edge) · the same entry in another collection · chain D against D, TM-score 1.00
- E2AB17 · AlphaFold monomer V2.0 prediction for brisc complex subunit FAM175B (E2AB17) · a predicted model of the same protein · chain D against A, TM-score 0.98
- E2AXC7 · AlphaFold monomer V2.0 prediction for lys-63-specific deubiquitinase BRCC36 (E2AXC7) · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E2AXC7
- Every structure of UniProt E2AB17
- Elsewhere: RCSB PDB 5CW3 · PDBe 5CW3 · UniProt E2AXC7 · UniProt E2AB17
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