Research workbench
Crystal structure of a human tcf-4 / beta-catenin complex
Analyse Crystal structure of a human tcf-4 / beta-catenin complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1JPW
- Type
- protein
- Length
- 1,578 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beta-catenin; Transcription factor 7-like 2
- UniProt
- P35222, Q9NQB0
- Pockets
- 8 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | Beta-catenin | protein | 502 | 75% helix, 0% strand | P35222 |
| D, E, F | Transcription factor 7-like 2 | protein | 24 | 33% helix, 0% strand | Q9NQB0 |
Pockets
8 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 926 | 0.72 | 0.76 | 96 | empty |
| 2 | 199 | 0.51 | 0.77 | 33 | empty |
| 3 | 192 | 0.51 | 0.77 | 28 | empty |
| 4 | 288 | 0.49 | 0.73 | 31 | empty |
| 5 | 60 | 0.35 | 0.78 | 13 | empty |
Interfaces
6 interfaces between chains.
- A–D · 1383 Ų buried · 22 hydrogen bonds · protein-protein
- B–E · 1378 Ų buried · 20 hydrogen bonds · protein-protein
- C–F · 1368 Ų buried · 20 hydrogen bonds · protein-protein
- B–C · 860 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 120 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 1JPW · Crystal Structure of a Human Tcf-4 / beta-Catenin Complex · the same entry in another collection · chain F against F, TM-score 1.00
- P35222 · AlphaFold monomer V2.0 prediction for catenin beta-1 (P35222) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q9NQB0 · AlphaFold monomer V2.0 prediction for transcription factor 7-like 2 (Q9NQB0) · a predicted model of the same protein · chain D against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35222
- Every structure of UniProt Q9NQB0
- Elsewhere: RCSB PDB 1JPW · PDBe 1JPW · UniProt P35222 · UniProt Q9NQB0
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