Research workbench
Solution structure of the BRCA1/BARD1 ring-domain heterodimer
Analyse Solution structure of the BRCA1/BARD1 ring-domain heterodimer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1JM7
- Type
- protein
- Length
- 200 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Breast cancer type 1 susceptibility protein; BRCA1-associated ring domain protein 1
- UniProt
- P38398, Q99728
- Ligands
- ZN
- Pockets
- 2 · best druggability 0.35
Structure
solution nmr · 2 distinct chains · 38% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Breast cancer type 1 susceptibility protein | protein | 103 | 40% helix, 2% strand | P38398 |
| B | BRCA1-associated ring domain protein 1 | protein | 97 | 35% helix, 4% strand | Q99728 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 83 | 0.35 | 0.75 | 20 | empty |
| 2 | 58 | 0.35 | 0.78 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1448 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 1JM7 · Solution structure of the BRCA1/BARD1 RING-domain heterodimer · the same entry in another collection · chain A against A, TM-score 1.00
- P38398 · AlphaFold monomer V2.0 prediction for breast cancer type 1 susceptibility protein (P38398) · a predicted model of the same protein · chain A against A, TM-score 0.82
- Q99728 · AlphaFold monomer V2.0 prediction for BRCA1-associated ring domain protein 1 (Q99728) · a predicted model of the same protein · chain B against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P38398
- Every structure of UniProt Q99728
- Elsewhere: RCSB PDB 1JM7 · PDBe 1JM7 · UniProt P38398 · UniProt Q99728
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