Research workbench
PI3K P85 C-terminal SH2 DOMAIN/CD28-derived peptide complex
Analyse PI3K P85 C-terminal SH2 DOMAIN/CD28-derived peptide complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5AUL
- Type
- protein
- Length
- 115 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol 3-kinase regulatory subunit alpha; T-cell-specific surface…
- UniProt
- P27986, P10747
Structure
x-ray diffraction · 2 distinct chains · 24% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol 3-kinase regulatory subunit alpha | protein | 109 | 26% helix, 28% strand | P27986 |
| B | T-cell-specific surface glycoprotein CD28 | protein | 6 | 0% helix, 0% strand | P10747 |
Ligands and binding sites
- GOL · Glycerol · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 525 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (oxidation, phosphorylation).
Compared structures
- 5AUL · PI3K p85 C-terminal SH2 domain/CD28-derived peptide complex · the same entry in another collection · chain A against A, TM-score 1.00
- P10747 · AlphaFold monomer V2.0 prediction for T-cell-specific surface glycoprotein CD28 (P10747) · a predicted model of the same protein · chain B against A, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27986
- Every structure of UniProt P10747
- Elsewhere: RCSB PDB 5AUL · PDBe 5AUL · UniProt P27986 · UniProt P10747
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