Research workbench
Bovine mitochondrial ATP synthase state 1B
Analyse Bovine mitochondrial ATP synthase state 1B in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5ARE
- Type
- protein
- Length
- 4,638 residues
- Chains
- 22
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP synthase subunit alpha, mitochondrial; ATP synthase subunit beta, mitochondrial; ATP…
- EC
- 3.6.3.14
- UniProt
- P19483, P00829, P05631, P05630, P05632, P32876, P13621, P13619, P13620, P02721, P00847
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 14 distinct chains · 47% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | ATP synthase subunit alpha, mitochondrial | protein | 509 | 41% helix, 18% strand | P19483 |
| B | ATP synthase subunit alpha, mitochondrial | protein | 480 | 41% helix, 21% strand | P19483 |
| C | ATP synthase subunit alpha, mitochondrial | protein | 487 | 43% helix, 19% strand | P19483 |
| D | ATP synthase subunit beta, mitochondrial (EC 3.6.3.14) | protein | 467 | 38% helix, 22% strand | P00829 |
| E, F | ATP synthase subunit beta, mitochondrial (EC 3.6.3.14) | protein | 466 | 38% helix, 22% strand | P00829 |
| G | ATP synthase subunit gamma, mitochondrial | protein | 264 | 55% helix, 9% strand | P05631 |
| H | ATP synthase subunit delta, mitochondrial | protein | 131 | 28% helix, 42% strand | P05630 |
| I | ATP synthase subunit epsilon, mitochondrial | protein | 47 | 49% helix, 4% strand | P05632 |
| J, K, L, M, N, O, P, Q | ATP synthase F(0) complex subunit C1, mitochondrial | protein | 72 | 67% helix, 0% strand | P32876 |
| S | ATP synthase subunit O, mitochondrial | protein | 167 | 38% helix, 0% strand | P13621 |
| T | ATP synthase F(0) complex subunit B1, mitochondrial | protein | 174 | 91% helix, 0% strand | P13619 |
| U | ATP synthase subunit D, mitochondrial | protein | 121 | 66% helix, 0% strand | P13620 |
| V | ATP synthase-coupling factor 6, mitochondrial | protein | 66 | 48% helix, 0% strand | P02721 |
| W | ATP synthase subunit beta, mitochondrial | protein | 217 | 81% helix, 0% strand | P00847 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 662 | 0.82 | 0.88 | 121 | empty |
| 2 | 795 | 0.80 | 0.84 | 138 | empty |
| 3 | 384 | 0.76 | 0.87 | 60 | empty |
| 4 | 808 | 0.75 | 0.80 | 118 | empty |
| 5 | 1083 | 0.75 | 0.78 | 137 | empty |
Interfaces
33 interfaces between chains.
- L–M · 552 Ų buried · 5 hydrogen bonds · protein-protein
- J–Q · 532 Ų buried · 5 hydrogen bonds · protein-protein
- P–Q · 525 Ų buried · 4 hydrogen bonds · protein-protein
- T–U · 522 Ų buried · 0 hydrogen bonds · protein-protein
- C–D · 521 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 5ARE · Bovine mitochondrial ATP synthase state 1b · the same entry in another collection · chain K against K, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19483
- Every structure of UniProt P00829
- Every structure of UniProt P05631
- Every structure of UniProt P05630
- Every structure of UniProt P05632
- Every structure of UniProt P32876
- Every structure of UniProt P13621
- Every structure of UniProt P13619
- Every structure of UniProt P13620
- Every structure of UniProt P02721
- Every structure of UniProt P00847
- Elsewhere: RCSB PDB 5ARE · PDBe 5ARE · UniProt P19483 · UniProt P00829 · UniProt P05631 · UniProt P05630 · UniProt P05632 · UniProt P32876 · UniProt P13621 · UniProt P13619 · UniProt P13620 · UniProt P02721 · UniProt P00847
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