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Ternary crystal structure of pyrococcus furiosus glyoxylate hydroxypyruvate reductase in presence of glyoxylate
Analyse Ternary crystal structure of pyrococcus furiosus glyoxylate hydroxypyruvate… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5AOV
- Type
- protein
- Length
- 334 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glyoxylate reductase
- EC
- 1.1.1.26, 1.1.1.81, 1.1.1.79
- UniProt
- I6UZH5
- Ligands
- GLV, NAP
- Pockets
- 1 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glyoxylate reductase (EC 1.1.1.26, 1.1.1.81, 1.1.1.79) | protein | 334 | 39% helix, 15% strand | I6UZH5 |
Ligands and binding sites
- GLV · Glyoxylic acid · ligand · 2 copies · chains A
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · chains A
- 1PE · Pentaethylene glycol · additive · 15 copies · chains A
- EDO · 1,2-ethanediol · additive · 5 copies · chains A
- ACY · Acetic acid · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 681 | 0.72 | 0.79 | 68 | NAP, GLV, ACY |
Compared structures
- 5AOV · Ternary Crystal Structure of Pyrococcus furiosus Glyoxylate Hydroxypyruvate Reductase in… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt I6UZH5
- Elsewhere: RCSB PDB 5AOV · PDBe 5AOV · UniProt I6UZH5
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