Research workbench
Crystal structure of EGFR kinase domain in complex with mitogen- inducible gene 6 protein
Analyse Crystal structure of EGFR kinase domain in complex with mitogen- inducible gene… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ZJV
- Type
- protein
- Length
- 647 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Epidermal growth factor receptor; Erbb receptor feedback inhibitor 1
- EC
- 2.7.10.1
- UniProt
- P00533, Q9UJM3
- Pockets
- 6 · best druggability 0.73
Structure
x-ray diffraction · 4 distinct chains · 35% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Epidermal growth factor receptor (EC 2.7.10.1) | protein | 282 | 39% helix, 22% strand | P00533 |
| B | Epidermal growth factor receptor (EC 2.7.10.1) | protein | 273 | 41% helix, 22% strand | P00533 |
| C | Erbb receptor feedback inhibitor 1 | protein | 48 | 6% helix, 33% strand | Q9UJM3 |
| D | Erbb receptor feedback inhibitor 1 | protein | 44 | 7% helix, 20% strand | Q9UJM3 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 638 | 0.73 | 0.80 | 73 | empty |
| 2 | 660 | 0.71 | 0.78 | 68 | empty |
| 3 | 399 | 0.60 | 0.76 | 51 | empty |
| 4 | 96 | 0.33 | 0.73 | 20 | empty |
| 5 | 61 | 0.30 | 0.74 | 20 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1689 Ų buried · 23 hydrogen bonds · protein-protein
- B–D · 1624 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 434 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (phosphorylation).
Compared structures
- 4ZJV · crystal structure of EGFR kinase domain in complex with Mitogen-inducible gene 6 protein · the same entry in another collection · chain D against D, TM-score 1.00
- P00533 · AlphaFold monomer V2.0 prediction for epidermal growth factor receptor (P00533) · a predicted model of the same protein · chain B against A, TM-score 0.94
- Q9UJM3 · AlphaFold monomer V2.0 prediction for erbb receptor feedback inhibitor 1 (Q9UJM3) · a predicted model of the same protein · chain D against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00533
- Every structure of UniProt Q9UJM3
- Elsewhere: RCSB PDB 4ZJV · PDBe 4ZJV · UniProt P00533 · UniProt Q9UJM3
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