Blood dendritic cell antigen 2 (bdca-2) complexed with galglcnacman

Structure

x-ray diffraction · 1 distinct chain · 14% helix, 38% strand (DSSP).

Ligands and binding sites

• MAN · alpha-D-mannopyranose · sugar · 2 copies · chains A, B
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B
• GAL · beta-D-galactopyranose · sugar · 2 copies · chains A, B
• CA · Calcium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 465 Ų buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 8 disulfide (disulfide).

Compared structures

• 4ZET · Blood dendritic cell antigen 2 (BDCA-2) complexed with GalGlcNAcMan · the same entry in another collection · chain A against A, TM-score 1.00
• Q8WTT0 · AlphaFold monomer V2.0 prediction for C-type lectin domain family 4 member C (Q8WTT0) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q8WTT0
• Elsewhere: RCSB PDB 4ZET · PDBe 4ZET · UniProt Q8WTT0