Research workbench
Crystal structure of the mavs-TRAF6 complex
Analyse Crystal structure of the mavs-TRAF6 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4Z8M
- Type
- protein
- Length
- 326 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TNF receptor-associated factor 6; Peptide from mitochondrial antiviral-signaling protein
- EC
- 6.3.2.-
- UniProt
- Q9Y4K3, Q7Z434
- Pockets
- 2 · best druggability 0.33
Structure
x-ray diffraction · 4 distinct chains · 12% helix, 43% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TNF receptor-associated factor 6 (EC 6.3.2.-) | protein | 152 | 12% helix, 45% strand | Q9Y4K3 |
| B | TNF receptor-associated factor 6 (EC 6.3.2.-) | protein | 158 | 13% helix, 41% strand | Q9Y4K3 |
| C | Peptide from mitochondrial antiviral-signaling protein | protein | 9 | 0% helix, 44% strand | Q7Z434 |
| D | Peptide from mitochondrial antiviral-signaling protein | protein | 7 | 0% helix, 57% strand | Q7Z434 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 81 | 0.33 | 0.74 | 16 | empty |
| 2 | 57 | 0.26 | 0.73 | 13 | empty |
Interfaces
6 interfaces between chains.
- A–C · 558 Ų buried · 11 hydrogen bonds · protein-protein
- B–D · 479 Ų buried · 10 hydrogen bonds · protein-protein
- A–D · 190 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 182 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 177 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 4Z8M · Crystal structure of the MAVS-TRAF6 complex · the same entry in another collection · chain D against D, TM-score 1.00
- Q9Y4K3 · AlphaFold monomer V2.0 prediction for TNF receptor-associated factor 6 (Q9Y4K3) · a predicted model of the same protein · chain A against A, TM-score 0.98
- Q7Z434 · AlphaFold monomer V2.0 prediction for mitochondrial antiviral- signaling protein (Q7Z434) · a predicted model of the same protein · chain D against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y4K3
- Every structure of UniProt Q7Z434
- Elsewhere: RCSB PDB 4Z8M · PDBe 4Z8M · UniProt Q9Y4K3 · UniProt Q7Z434
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