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High resolution human septin 3 GTPase domain

Analyse High resolution human septin 3 GTPase domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4Z51
Type: protein
Length: 253 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neuronal-specific septin-3
UniProt: Q9UH03
Ligands: GNP, MG
Pockets: 2 · best druggability 0.51

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neuronal-specific septin-3	protein	253	41% helix, 20% strand	Q9UH03

Ligands and binding sites

GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
MG · Magnesium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	169	0.51	0.78	34	GNP, MG
2	60	0.33	0.76	16	empty

Compared structures

4Z51 · High Resolution Human Septin 3 GTPase domain · the same entry in another collection · chain A against A, TM-score 1.00
Q9UH03 · AlphaFold monomer V2.0 prediction for neuronal-specific septin-3 (Q9UH03) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UH03
Elsewhere: RCSB PDB 4Z51 · PDBe 4Z51 · UniProt Q9UH03

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