Research workbench
CDK1/CKS1
Analyse CDK1/CKS1 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4YC6
- Type
- protein
- Length
- 1,420 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cyclin-dependent kinase 1; Cyclin-dependent kinases regulatory subunit 1
- EC
- 2.7.11.22, 2.7.11.23
- UniProt
- P06493, P61024
- Pockets
- 17 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E, G | Cyclin-dependent kinase 1 (EC 2.7.11.22, 2.7.11.23) | protein | 285 | 35% helix, 16% strand | P06493 |
| B, D, F, H | Cyclin-dependent kinases regulatory subunit 1 | protein | 70 | 16% helix, 31% strand | P61024 |
Pockets
17 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 677 | 0.81 | 0.85 | 71 | empty |
| 2 | 675 | 0.81 | 0.85 | 69 | empty |
| 3 | 831 | 0.80 | 0.83 | 71 | empty |
| 4 | 1075 | 0.79 | 0.80 | 70 | empty |
| 5 | 744 | 0.75 | 0.80 | 85 | empty |
Interfaces
16 interfaces between chains.
- A–G · 1265 Ų buried · 25 hydrogen bonds · protein-protein
- C–E · 1195 Ų buried · 22 hydrogen bonds · protein-protein
- G–H · 787 Ų buried · 14 hydrogen bonds · protein-protein
- E–F · 786 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 782 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06493
- Every structure of UniProt P61024
- Elsewhere: RCSB PDB 4YC6 · PDBe 4YC6 · UniProt P06493 · UniProt P61024
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