UniProt P06493
Cyclin-dependent kinase 1 (P06493)
Cyclin-dependent kinase 1 (UniProt P06493), EC 2.7.11.22, 2.7.11.23: 21 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 11 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P06493
- Protein
- Cyclin-dependent kinase 1
- EC
- 2.7.11.22, 2.7.11.23
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 11 · 2 records with a druggable one
Structures
22 records of P06493 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4Y72 | Human CDK1/CyclinB1/CKS2 With Inhibitor | x-ray diffraction | A | — | — |
| 4Y72 | Human CDK1/CYCLINB1/CKS2 with inhibitor | x-ray diffraction | A | — | — |
| 4YC3 | CDK1/CyclinB1/CKS2 Apo | x-ray diffraction | A | — | — |
| 4YC3 | CDK1/CYCLINB1/CKS2 apo | x-ray diffraction | A | — | — |
| 4YC6 | CDK1/CKS1 | x-ray diffraction | A, C, E, G | — | — |
| 4YC6 | CDK1/CKS1 | x-ray diffraction | A, C, E, G | — | — |
| 5HQ0 | Ternary complex of human proteins CDK1, Cyclin B and CKS2, bound to an inhibitor | x-ray diffraction | A | LZ9 | — |
| 5HQ0 | Ternary complex of human proteins CDK1, cyclin B and CKS2, bound to an inhibitor | x-ray diffraction | A | — | — |
| 5LQF | CDK1/CyclinB1/CKS2 in complex with NU6102 | x-ray diffraction | A, D | 4SP | — |
| 5LQF | CDK1/CYCLINB1/CKS2 in complex with NU6102 | x-ray diffraction | A, D | 4SP | — |
| 6GU2 | CDK1/CyclinB/Cks2 in complex with Flavopiridol | x-ray diffraction | A | F9Z | — |
| 6GU2 | CDK1/CYCLINB/CKS2 in complex with flavopiridol | x-ray diffraction | A | F9Z | — |
| 6GU3 | CDK1/CyclinB/Cks2 in complex with AZD5438 | x-ray diffraction | A | FB8 | 7 (best 0.69) |
| 6GU3 | CDK1/CYCLINB/CKS2 in complex with AZD5438 | x-ray diffraction | A | FB8 | — |
| 6GU4 | CDK1/CYCLINB/CKS2 in complex with CGP74514A | x-ray diffraction | A | FC8 | — |
| 6GU6 | CDK1/CKS2 in complex with dinaciclib | x-ray diffraction | A | 1QK | — |
| 6GU7 | CDK1/CKS2 in complex with AZD5438 | x-ray diffraction | A, C, E, G | FB8 | — |
| 6TWN | Crystal structure of Talin1 R7R8 in complex with CDK1 (206-223) | x-ray diffraction | C, D | — | — |
| 6TWN | Crystal structure of TALIN1 R7R8 in complex with CDK1 (206-223) | x-ray diffraction | C, D | — | — |
| 7NJ0 | CryoEM structure of the human Separase-Cdk1-cyclin B1-Cks1 complex | electron microscopy | B | — | 4 (best 0.74) |
| 7NJ0 | Cryoem structure of the human separase-CDK1-cyclin B1-CKS1 complex | electron microscopy | B | — | — |
| P06493 | AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 1 (P06493) | predicted | A | — | — |
Ligands
- FB8 · 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine · in 3 records
- 4SP · O6-cyclohexylmethoxy-2-(4'-sulphamoylanilino) purine · in 2 records
- F9Z · 2-(2-chlorophenyl)-8-[(3~{R},4~{R})-1-methyl-3-oxidanyl-piperidin-4-yl]-5,7-bis(oxidanyl)chromen-4-one · in 2 records
- 1QK · 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium · in 1 record
- FC8 · ~{N}2-[(1~{R},2~{S})-2-azanylcyclohexyl]-~{N}6-(3-chlorophenyl)-9-ethyl-purine-2,6-diamine · in 1 record
- LZ9 · {[(2,6-difluorophenyl)carbonyl]amino}-N-(4-fluorophenyl)-1H-pyrazole-3-carboxamide · in 1 record
Experiment against prediction
- 6GU7 chain E against the predicted model P06493: TM-score 0.96, RMSD 1.56 Å
- 6GU7 chain C against the predicted model P06493: TM-score 0.96, RMSD 1.57 Å
- 4YC6 chain E against the predicted model P06493: TM-score 0.96, RMSD 1.56 Å
- 4YC6 chain E against the predicted model P06493: TM-score 0.96, RMSD 1.56 Å
- 6GU6 chain A against the predicted model P06493: TM-score 0.96, RMSD 1.69 Å
- 6GU7 chain A against the predicted model P06493: TM-score 0.96, RMSD 1.63 Å
- 4YC6 chain C against the predicted model P06493: TM-score 0.96, RMSD 1.47 Å
- 4YC6 chain C against the predicted model P06493: TM-score 0.96, RMSD 1.47 Å
- 4YC6 chain A against the predicted model P06493: TM-score 0.96, RMSD 1.51 Å
- 4YC6 chain A against the predicted model P06493: TM-score 0.96, RMSD 1.51 Å
Elsewhere
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