Research workbench
Crystal structure of the hect domain of human WWP2
Analyse Crystal structure of the hect domain of human WWP2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4Y07
- Type
- protein
- Length
- 333 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NEDD4-like E3 ubiquitin-protein ligase WWP2
- EC
- 6.3.2.-
- UniProt
- O00308
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 1 distinct chain · 53% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 6.3.2.-) | protein | 333 | 53% helix, 11% strand | O00308 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 165 | 0.72 | 0.90 | 29 | empty |
| 2 | 277 | 0.68 | 0.84 | 44 | empty |
| 3 | 69 | 0.33 | 0.76 | 17 | empty |
Compared structures
- 4Y07 · Crystal structure of the HECT domain of human WWP2 · the same entry in another collection · chain A against A, TM-score 1.00
- O00308 · AlphaFold monomer V2.0 prediction for NEDD4-like E3 ubiquitin-protein ligase WWP2 (O00308) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O00308
- Elsewhere: RCSB PDB 4Y07 · PDBe 4Y07 · UniProt O00308
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