Research workbench
MGLUR2 ecd and MGLUR3 ecd complex with ligands
Analyse MGLUR2 ecd and MGLUR3 ecd complex with ligands in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4XAR
- Type
- protein
- Length
- 445 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Metabotropic glutamate receptor 3
- UniProt
- Q14832
- Ligands
- 40F, IOD
- Pockets
- 5 · best druggability 0.67
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Metabotropic glutamate receptor 3 | protein | 445 | 36% helix, 21% strand | Q14832 |
Ligands and binding sites
- 40F · (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid · ligand · chains A
- IOD · Iodide ion · ion · 8 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 155 | 0.67 | 0.88 | 38 | 40F, IOD |
| 2 | 430 | 0.64 | 0.77 | 47 | IOD |
| 3 | 113 | 0.60 | 0.86 | 30 | empty |
| 4 | 82 | 0.43 | 0.80 | 25 | empty |
| 5 | 52 | 0.30 | 0.77 | 15 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14832
- Elsewhere: RCSB PDB 4XAR · PDBe 4XAR · UniProt Q14832
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