Research workbench
Heterodimer of importin alpha 1 with nuclear localization signal of TAF8
Analyse Heterodimer of importin alpha 1 with nuclear localization signal of TAF8 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4WV6
- Type
- protein
- Length
- 438 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; Transcription initiation factor tfiid subunit 8
- UniProt
- P52292, Q7Z7C8
- Pockets
- 1 · best druggability 0.52
Structure
x-ray diffraction · 3 distinct chains · 73% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha-1 | protein | 426 | 75% helix, 0% strand | P52292 |
| B | Transcription initiation factor tfiid subunit 8 | protein | 9 | 0% helix, 0% strand | Q7Z7C8 |
| C | Transcription initiation factor tfiid subunit 8 | protein | 3 | 0% helix, 0% strand | Q7Z7C8 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 12 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.52 | 0.88 | 13 | empty |
Interfaces
2 interfaces between chains.
- A–B · 665 Ų buried · 16 hydrogen bonds · protein-protein
- A–C · 319 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 4WV6 · Heterodimer of Importin alpha 1 with nuclear localization signal of TAF8 · the same entry in another collection · chain A against A, TM-score 1.00
- Q7Z7C8 · AlphaFold monomer V2.0 prediction for transcription initiation factor tfiid subunit 8… · a predicted model of the same protein · chain C against A, TM-score 0.99
- P52292 · AlphaFold monomer V2.0 prediction for importin subunit alpha-1 (P52292) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52292
- Every structure of UniProt Q7Z7C8
- Elsewhere: RCSB PDB 4WV6 · PDBe 4WV6 · UniProt P52292 · UniProt Q7Z7C8
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