Research workbench
Crystal structure of influenza B polymerase bound to the vrna promoter (FLUB1 form)
Analyse Crystal structure of influenza B polymerase bound to the vrna promoter (FLUB1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4WSA
- Type
- protein + RNA
- Length
- 2,207 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Influenza B vrna promoter 3' end; Influenza B vrna promoter 5' end; Pa; RNA-directed RNA…
- EC
- 2.7.7.48
- UniProt
- Q5V8Z9, Q5V8Y6, Q5V8X3
- Pockets
- 20 · best druggability 0.88
Structure
x-ray diffraction · 5 distinct chains · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | Influenza B vrna promoter 3' end | rna | 14 | — | — |
| V | Influenza B vrna promoter 5' end | rna | 14 | — | — |
| A | Pa | protein | 716 | 45% helix, 16% strand | Q5V8Z9 |
| B | RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) | protein | 733 | 48% helix, 16% strand | Q5V8Y6 |
| C | PB2 | protein | 730 | 37% helix, 22% strand | Q5V8X3 |
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1154 | 0.88 | 0.89 | 142 | empty |
| 2 | 1103 | 0.79 | 0.81 | 70 | empty |
| 3 | 1031 | 0.78 | 0.80 | 79 | empty |
| 4 | 630 | 0.75 | 0.81 | 70 | empty |
| 5 | 339 | 0.74 | 0.86 | 48 | empty |
Interfaces
9 interfaces between chains.
- A–B · 8966 Ų buried · 127 hydrogen bonds · protein-protein
- B–C · 6773 Ų buried · 77 hydrogen bonds · protein-protein
- A–C · 2153 Ų buried · 24 hydrogen bonds · protein-protein
- V–A · 1270 Ų buried · 25 hydrogen bonds · protein-nucleic
- V–B · 575 Ų buried · 6 hydrogen bonds · protein-nucleic
Compared structures
- 4WSA · Crystal structure of Influenza B polymerase bound to the vRNA promoter (FluB1 form) · the same entry in another collection · chain R against R, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5V8Z9
- Every structure of UniProt Q5V8Y6
- Every structure of UniProt Q5V8X3
- Elsewhere: RCSB PDB 4WSA · PDBe 4WSA · UniProt Q5V8Z9 · UniProt Q5V8Y6 · UniProt Q5V8X3
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