Research workbench
Crystal structure of MUCH37-HRPN13 ctd-hub complex
Analyse Crystal structure of MUCH37-HRPN13 ctd-hub complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4WLR
- Type
- protein
- Length
- 471 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin carboxyl-terminal hydrolase isozyme L5; Proteasomal ubiquitin receptor ADRM1…
- EC
- 3.4.19.12
- UniProt
- Q9WUP7, Q16186, P0CG47
- Pockets
- 4 · best druggability 0.70
Structure
x-ray diffraction · 3 distinct chains · 49% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin carboxyl-terminal hydrolase isozyme L5 (EC 3.4.19.12) | protein | 296 | 49% helix, 16% strand | Q9WUP7 |
| B | Proteasomal ubiquitin receptor ADRM1 | protein | 99 | 71% helix, 2% strand | Q16186 |
| C | Polyubiquitin-B | protein | 76 | 24% helix, 37% strand | P0CG47 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 481 | 0.70 | 0.80 | 44 | empty |
| 2 | 70 | 0.70 | 0.96 | 23 | empty |
| 3 | 160 | 0.44 | 0.75 | 28 | empty |
| 4 | 93 | 0.41 | 0.78 | 24 | empty |
Interfaces
3 interfaces between chains.
- A–B · 2129 Ų buried · 12 hydrogen bonds · protein-protein
- A–C · 1247 Ų buried · 19 hydrogen bonds · protein-protein
- B–C · 285 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 4WLR · Crystal Structure of mUCH37-hRPN13 CTD-hUb complex · the same entry in another collection · chain A against A, TM-score 1.00
- Q9WUP7 · AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase isozyme L5… · a predicted model of the same protein · chain A against A, TM-score 0.96
- Q16186 · AlphaFold monomer V2.0 prediction for proteasomal ubiquitin receptor ADRM1 (Q16186) · a predicted model of the same protein · chain B against A, TM-score 0.71
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WUP7
- Every structure of UniProt Q16186
- Every structure of UniProt P0CG47
- Elsewhere: RCSB PDB 4WLR · PDBe 4WLR · UniProt Q9WUP7 · UniProt Q16186 · UniProt P0CG47
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