UniProt Q16186
Proteasomal ubiquitin receptor ADRM1 (Q16186)
Proteasomal ubiquitin receptor ADRM1 (UniProt Q16186): 32 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 13 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q16186
- Protein
- Proteasomal ubiquitin receptor ADRM1
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 13 · 3 records with a druggable one
Structures
33 records of Q16186 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KQZ | Solution structure of the Rpn13 DEUBAD domain | solution nmr | A | — | — |
| 2KQZ | Solution structure of the RPN13 deubad domain | solution nmr | A | — | — |
| 2KR0 | Solution structure of the proteasome ubiquitin receptor Rpn13 | solution nmr | A | — | — |
| 2KR0 | Solution structure of the proteasome ubiquitin receptor RPN13 | solution nmr | A | — | — |
| 2L5V | Solution structure of the C-terminal domain of hRpn13 | solution nmr | A | — | — |
| 2L5V | Solution structure of the C-terminal domain of HRPN13 | solution nmr | A | — | — |
| 2MKZ | solution structure of a protein C-terminal domain | solution nmr | A | — | — |
| 2MKZ | Solution structure of a protein C-terminal domain | solution nmr | A | — | — |
| 2NBV | Solution structure of the Rpn13 Pru domain engaging the hPLIC2 UBL domain | solution nmr | A | — | — |
| 2NBV | Solution structure of the RPN13 pru domain engaging the HPLIC2 ubl domain | solution nmr | A | — | — |
| 4UEL | UCH-L5 in complex with ubiquitin-propargyl bound to the RPN13 DEUBAD domain | x-ray diffraction | C | — | — |
| 4UEL | Uch-L5 in complex with ubiquitin-propargyl bound to the RPN13 deubad domain | x-ray diffraction | C | — | — |
| 4UEM | UCH-L5 in complex with the RPN13 DEUBAD domain | x-ray diffraction | B | — | — |
| 4UEM | Uch-L5 in complex with the RPN13 deubad domain | x-ray diffraction | B | — | — |
| 4WLQ | Crystal structure of MUCH37-HRPN13 ctd complex | x-ray diffraction | B | — | — |
| 4WLR | Crystal structure of MUCH37-HRPN13 ctd-hub complex | x-ray diffraction | B | — | — |
| 5IRS | crystal structure of the proteasomal Rpn13 PRU-domain | x-ray diffraction | A | — | — |
| 5IRS | Crystal structure of the proteasomal RPN13 pru-domain | x-ray diffraction | A | — | — |
| 5V1Y | Crystal structure of the ternary RPN13 pru-RPN2 (940-953)-ubiquitin complex | x-ray diffraction | A, B | — | — |
| 5V1Z | Crystal structure of the RPN13 pru-RPN2 (932-953)-ubiquitin complex | x-ray diffraction | A, B | — | — |
| 5YMY | The structure of the complex between Rpn13 and K48-diUb | solution nmr | C | — | 3 (best 0.55) |
| 5YMY | The structure of the complex between RPN13 and K48-diub | solution nmr | C | — | — |
| 6CO4 | Structure of the Rpn13-Rpn2 complex provides insights for Rpn13 and Uch37 as anticancer targets | solution nmr | A | — | — |
| 6CO4 | Structure of the RPN13-RPN2 complex provides insights for RPN13 and UCH37 as anticancer targets | solution nmr | A | — | — |
| 6OI4 | RPN13 (19-132)-RPN2 (940-952) pY950-Ub complex | x-ray diffraction | A, B | — | 5 (best 0.61) |
| 6OI4 | RPN13 (19-132)-RPN2 (940-952) PY950-ub complex | x-ray diffraction | A, B | — | — |
| 6UYI | HRPN13:HRPN2:K48-diubiquitin | solution nmr | A | — | — |
| 6UYJ | hRpn13:hRpn2:K48-diubiquitin | solution nmr | A | — | — |
| 6UYJ | HRPN13:HRPN2:K48-diubiquitin | solution nmr | A | — | — |
| 7KXI | Structure of XL5-ligated hRpn13 Pru domain | solution nmr | A | XAY | 1 (best 0.28) |
| 7KXI | Structure of XL5-ligated HRPN13 pru domain | solution nmr | A | XAY | — |
| 8FTQ | Crystal structure of hRpn13 Pru domain in complex with Ubiquitin and XL44 | x-ray diffraction | A, B | ZTO | 4 (best 0.70) |
| Q16186 | AlphaFold monomer V2.0 prediction for proteasomal ubiquitin receptor ADRM1 (Q16186) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6OI4 chain B against the predicted model Q16186: TM-score 0.97, RMSD 0.72 Å
- 6OI4 chain B against the predicted model Q16186: TM-score 0.97, RMSD 0.72 Å
- 5V1Z chain B against the predicted model Q16186: TM-score 0.97, RMSD 0.78 Å
- 5V1Z chain A against the predicted model Q16186: TM-score 0.96, RMSD 1.07 Å
- 5V1Y chain B against the predicted model Q16186: TM-score 0.96, RMSD 1.00 Å
- 8FTQ chain A against the predicted model Q16186: TM-score 0.96, RMSD 0.91 Å
- 8FTQ chain B against the predicted model Q16186: TM-score 0.96, RMSD 0.95 Å
- 5IRS chain A against the predicted model Q16186: TM-score 0.96, RMSD 0.98 Å
- 5IRS chain A against the predicted model Q16186: TM-score 0.96, RMSD 0.98 Å
- 6OI4 chain A against the predicted model Q16186: TM-score 0.95, RMSD 1.14 Å
Elsewhere
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